Artificial lungs: current status and future directions

RA Orizondo, AJ Cardounel, R Kormos… - Current Transplantation …, 2019 - Springer
Abstract Purpose of Review Although lung transplantation can be used to treat lung failure,
limited donor organ availability creates a pressing need for improved artificial lung …

In vivo carbon dioxide clearance of a low-flow extracorporeal carbon dioxide removal circuit in patients with acute exacerbations of chronic obstructive pulmonary …

NA Barrett, N Hart, L Camporota - Perfusion, 2020 - journals.sagepub.com
Background: Veno-venous extracorporeal carbon dioxide removal allows clearance of CO2
from the blood and is becoming popular to enhance protective mechanical ventilation and …

Month-long respiratory support by a wearable pumping artificial lung in an ovine model

RA Orizondo, KS Omecinski, AG May… - …, 2021 - journals.lww.com
Background. A wearable artificial lung could improve lung transplantation outcomes by
easing implementation of physical rehabilitation during long-term pretransplant respiratory …

Effect of hematocrit on the CO2 removal rate of artificial lungs

AG May, KS Omecinski, BJ Frankowski… - ASAIO …, 2020 - journals.lww.com
Abstract Extracorporeal CO 2 removal (ECCO 2 R) can permit lung protective or noninvasive
ventilation strategies in patients with chronic obstructive pulmonary disease (COPD) and …

Improvement of a Mathematical Model to Predict CO2 Removal in Hollow Fiber Membrane Oxygenators

KS Omecinski, WJ Federspiel - Bioengineering, 2022 - mdpi.com
The use of extracorporeal oxygenation and CO2 removal has gained clinical validity and
popularity in recent years. These systems are composed of a pump to drive blood flow …

The Effect of Sweeping Media and Temperature on Aqueous CO2 Removal Using Hollow Fiber Membrane Contactor (HFMC): An Experimental Determination

H Tabesh, MH Gholami… - International Journal of …, 2023 - Wiley Online Library
Transport phenomena through hollow fiber membrane contactors (HFMCs) indicate the
exchange of a component between the two phases, inside and outside of hollow fibers. In …

Suitable CO2 Solubility Models for Determination of the CO2 Removal Performance of Oxygenators

B Lukitsch, P Ecker, M Elenkov, C Janeczek, C Jordan… - Bioengineering, 2021 - mdpi.com
CO2 removal via membrane oxygenators during lung protective ventilation has become a
reliable clinical technique. For further optimization of oxygenators, accurate prediction of the …

Blood recirculation enhances oxygenation efficiency of artificial lungs

SP Madhani, AG May, BJ Frankowski… - ASAIO …, 2020 - journals.lww.com
Ambulating patients on extracorporeal membrane oxygenation (ECMO) or extracorporeal
CO 2 removal (ECCO 2 R) improves outcomes. These systems would further simplify …

In vitro characterization of PrismaLung+: a novel ECCO2R device

I Hospach, J Goldstein, K Harenski, JG Laffey… - Intensive Care Medicine …, 2020 - Springer
Background Invasive mechanical ventilation is lifesaving in the setting of severe acute
respiratory failure but can cause ventilation-induced lung injury. Advances in extracorporeal …

Preclinical Evaluation of a New ECCO2R Setup

LS Schwärzel, AM Jungmann, N Schmoll… - ASAIO …, 2022 - journals.lww.com
Low flow extracorporeal carbon dioxide removal (ECCO 2 R) is a promising approach to
correct hypercapnic lung failure, facilitate lung protective ventilation in acute respiratory …