Current state and future directions in the therapy of ALS
L Tzeplaeff, S Wilfling, MV Requardt, M Herdick - Cells, 2023 - mdpi.com
Amyotrophic lateral sclerosis (ALS) is a rapidly progressive neurodegenerative disorder
affecting upper and lower motor neurons, with death resulting mainly from respiratory failure …
affecting upper and lower motor neurons, with death resulting mainly from respiratory failure …
Real-world evidence of riluzole effectiveness in treating amyotrophic lateral sclerosis
JA Andrews, CE Jackson… - … Lateral Sclerosis and …, 2020 - Taylor & Francis
Objective To compare the effect of riluzole on median survival in population studies of
patients with amyotrophic lateral sclerosis (ALS) with that observed in clinical trials …
patients with amyotrophic lateral sclerosis (ALS) with that observed in clinical trials …
Canadian best practice recommendations for the management of amyotrophic lateral sclerosis
C Shoesmith, A Abrahao, T Benstead, M Chum… - Cmaj, 2020 - Can Med Assoc
The care and management of patients with ALS should always be patient focused, with
attention to holistic and emotional aspects of well-being. It is the patient who ultimately …
attention to holistic and emotional aspects of well-being. It is the patient who ultimately …
The gut microbiota-immunity axis in ALS: a role in deciphering disease heterogeneity?
Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disorder with an unknown
etiology and no effective treatment, and is characterized by large phenotypic heterogeneity …
etiology and no effective treatment, and is characterized by large phenotypic heterogeneity …
Epidemiological, clinical and genetic features of ALS in the last decade: a prospective population-based study in the Emilia Romagna region of Italy
G Gianferrari, I Martinelli, E Zucchi, C Simonini, N Fini… - Biomedicines, 2022 - mdpi.com
Increased incidence rates of amyotrophic lateral sclerosis (ALS) have been recently
reported across various Western countries, although geographic and temporal variations in …
reported across various Western countries, although geographic and temporal variations in …
Multidisciplinary care in amyotrophic lateral sclerosis: a systematic review and meta-analysis
FEO de Almeida, AK do Carmo Santana… - Neurological …, 2021 - Springer
Multidisciplinary care (MDC) has been the most recommended approach for symptom
management in amyotrophic lateral sclerosis (ALS) but there is conflicting evidence about its …
management in amyotrophic lateral sclerosis (ALS) but there is conflicting evidence about its …
Early initiation of riluzole may improve absolute survival in amyotrophic lateral sclerosis
NJ Thakore, BR Lapin, H Mitsumoto - Muscle & nerve, 2022 - Wiley Online Library
Abstract Introduction/Aims Riluzole improves survival in amyotrophic lateral sclerosis (ALS),
but optimal time and duration of treatment are unknown. The aim of this study was to …
but optimal time and duration of treatment are unknown. The aim of this study was to …
Predicting functional impairment trajectories in amyotrophic lateral sclerosis: a probabilistic, multifactorial model of disease progression
Abstract Objective To employ Artificial Intelligence to model, predict and simulate the
amyotrophic lateral sclerosis (ALS) progression over time in terms of variable interactions …
amyotrophic lateral sclerosis (ALS) progression over time in terms of variable interactions …
Effect of tauroursodeoxycholic acid on survival and safety in amyotrophic lateral sclerosis: a retrospective population-based cohort study
E Zucchi, UM Musazzi, G Fedele, I Martinelli… - …, 2023 - thelancet.com
Background Oral tauroursodeoxycholic acid (TUDCA) is a commercial drug currently tested
in patients with amyotrophic lateral sclerosis (ALS) both singly and combined with sodium …
in patients with amyotrophic lateral sclerosis (ALS) both singly and combined with sodium …
Clinical characteristics of a large cohort of US participants enrolled in the National Amyotrophic Lateral Sclerosis (ALS) Registry, 2010–2015
J Raymond, BÖ Oskarsson, P Mehta… - … Lateral Sclerosis and …, 2019 - Taylor & Francis
Background: Amyotrophic lateral sclerosis (ALS) is a progressive fatal disease with a
varying range of clinical characteristics. Objective: To describe the clinical characteristics in …
varying range of clinical characteristics. Objective: To describe the clinical characteristics in …