Sperm DNA integrity is crucial for fertilization and development of healthy offspring. The
spermatozoon undergoes extensive molecular remodeling of its nucleus during later phases …

Spermatogenesis is an extraordinary complex process. The differentiation of spermatogonia
into spermatozoa requires the participation of several cell types, hormones, paracrine …

Sperm DNA damage is prevalent among infertile men and is known to influence natural
reproduction. However, the impact of sperm DNA damage on assisted reproduction …

Sperm DNA fragmentation (SDF) has been generally acknowledged as a valuable tool for
male fertility evaluation. While its detrimental implications on sperm function were …

Sperm DNA fragmentation has been associated with reduced fertilization rates, embryo
quality, pregnancy rates and increased miscarriage rates. Various methods exist to test …

The clinical effect of sperm DNA damage in assisted reproduction has been a controversial
topic during recent decades, leading to a variety of clinical practice recommendations. While …

Redox degenerative reactions of the biological system inevitably produce reactive oxygen
species (ROS) and their derivatives. Oxidative stress is the result of an imbalance in pro …

Objective To examine whether sperm DNA fragmentation has an effect on pregnancy and
miscarriage after IVF and/or intracytoplasmic sperm injection (ICSI). Design Systematic …

A systematic review and meta-analysis was conducted to evaluate the relationship between
the extent of sperm DNA damage and live birth rate (LBR) per couple and the influence of …

Oxidative stress in the male germ line is thought to affect male fertility and impact upon
normal embryonic development. Accordingly, fertility specialists are actively exploring the …