[HTML][HTML] The osteosarcoma microenvironment: a complex but targetable ecosystem
Osteosarcomas are the most frequent primary bone sarcomas, affecting mainly children,
adolescents, and young adults, and with a second peak of incidence in elderly individuals …
adolescents, and young adults, and with a second peak of incidence in elderly individuals …
Therapy for osteosarcoma: where do we go from here?
AJ Chou, DS Geller, R Gorlick - Pediatric Drugs, 2008 - Springer
Osteosarcoma is the most common malignant primary bone tumor in children and
adolescents. Current optimal treatment for osteosarcoma consists of multi-agent …
adolescents. Current optimal treatment for osteosarcoma consists of multi-agent …
[HTML][HTML] Detection of circulating tumour DNA is associated with inferior outcomes in Ewing sarcoma and osteosarcoma: a report from the Children's Oncology Group
DS Shulman, K Klega, A Imamovic-Tuco… - British journal of …, 2018 - nature.com
Background New prognostic markers are needed to identify patients with Ewing sarcoma
(EWS) and osteosarcoma unlikely to benefit from standard therapy. We describe the …
(EWS) and osteosarcoma unlikely to benefit from standard therapy. We describe the …
Synergistic Chemoimmunotherapy Augmentation via Sequential Nanocomposite Hydrogel‐Mediated Reprogramming of Cancer‐Associated Fibroblasts in …
In osteosarcoma, immunotherapy often faces hurdles posed by cancer‐associated
fibroblasts (CAFs) that secrete dense extracellular matrix components and cytokines …
fibroblasts (CAFs) that secrete dense extracellular matrix components and cytokines …
Prognostic factors in localized extremity osteosarcoma: a systematic review
JAM Bramer, JH van Linge, RJ Grimer… - European Journal of …, 2009 - Elsevier
AIM: Finding reliable prognostic factors for osteosarcoma remains problematic. A systematic
review [Davis AM, Bell RS, Goodwin PJ. Prognostic factors in osteosarcoma: a critical …
review [Davis AM, Bell RS, Goodwin PJ. Prognostic factors in osteosarcoma: a critical …
Markers of angiogenesis and clinical features in patients with sarcoma
S DuBois, G Demetri - … Journal of the American Cancer Society, 2007 - Wiley Online Library
The growth and dissemination of sarcomas depends on angiogenesis. A number of
measurable markers related to tumor angiogenesis have been studied in patients with …
measurable markers related to tumor angiogenesis have been studied in patients with …
[HTML][HTML] CXCR4 and VEGF expression in the primary site and the metastatic site of human osteosarcoma: analysis within a group of patients, all of whom developed …
Y Oda, H Yamamoto, S Tamiya, S Matsuda, K Tanaka… - Modern Pathology, 2006 - Elsevier
The chemokine, CXCL12, and its receptor, CXCR4, have recently been shown to play an
important role in metastasis of several kinds of carcinoma. It has also been demonstrated …
important role in metastasis of several kinds of carcinoma. It has also been demonstrated …
Targets for cancer therapy in childhood sarcomas
M Wachtel, BW Schäfer - Cancer treatment reviews, 2010 - Elsevier
Development of chemotherapeutic treatment modalities resulted in a dramatic increase in
the survival of children with many types of cancer. Still, in case of some pediatric cancer …
the survival of children with many types of cancer. Still, in case of some pediatric cancer …
Recent advances in the management of osteosarcoma and forthcoming therapeutic strategies
F Lamoureux, V Trichet, C Chipoy… - Expert review of …, 2007 - Taylor & Francis
Osteosarcoma is the most frequent primary bone tumor and occurs mainly in young patients
(average age: 18 years). No evolution of the survival rates has been recorded for two …
(average age: 18 years). No evolution of the survival rates has been recorded for two …
A phase II trial evaluating the feasibility of adding bevacizumab to standard osteosarcoma therapy
F Navid, VM Santana, M Neel… - … journal of cancer, 2017 - Wiley Online Library
Increased vascular endothelial growth factor (VEGF) expression in osteosarcoma correlates
with a poor outcome. We conducted a phase II trial to evaluate the feasibility and efficacy of …
with a poor outcome. We conducted a phase II trial to evaluate the feasibility and efficacy of …