Osteosarcomas are the most frequent primary bone sarcomas, affecting mainly children,
adolescents, and young adults, and with a second peak of incidence in elderly individuals …

Osteosarcoma is the most common malignant primary bone tumor in children and
adolescents. Current optimal treatment for osteosarcoma consists of multi-agent …

Background New prognostic markers are needed to identify patients with Ewing sarcoma
(EWS) and osteosarcoma unlikely to benefit from standard therapy. We describe the …

In osteosarcoma, immunotherapy often faces hurdles posed by cancer‐associated
fibroblasts (CAFs) that secrete dense extracellular matrix components and cytokines …

AIM: Finding reliable prognostic factors for osteosarcoma remains problematic. A systematic
review [Davis AM, Bell RS, Goodwin PJ. Prognostic factors in osteosarcoma: a critical …

The growth and dissemination of sarcomas depends on angiogenesis. A number of
measurable markers related to tumor angiogenesis have been studied in patients with …

The chemokine, CXCL12, and its receptor, CXCR4, have recently been shown to play an
important role in metastasis of several kinds of carcinoma. It has also been demonstrated …

Development of chemotherapeutic treatment modalities resulted in a dramatic increase in
the survival of children with many types of cancer. Still, in case of some pediatric cancer …

Osteosarcoma is the most frequent primary bone tumor and occurs mainly in young patients
(average age: 18 years). No evolution of the survival rates has been recorded for two …

Increased vascular endothelial growth factor (VEGF) expression in osteosarcoma correlates
with a poor outcome. We conducted a phase II trial to evaluate the feasibility and efficacy of …