Wnt signaling determines major developmental processes in the embryonic state and
regulates maintenance, self-renewal and differentiation of adult mammalian tissue stem …

Dopaminergic (DA) neurons of the ventral midbrain (VM) play vital roles in the regulation of
voluntary movement, emotion and reward. They are divided into the A8, A9 and A10 …

The first mammalian Wnt to be discovered, Wnt-1, was found to be essential for the
development of a large part of the mouse brain over 25 years ago. We have since learned …

Neural stem/progenitor cells (NSCs) maintain the ability of self-renewal and differentiation
and compose the complex nervous system. Wnt signaling is thought to control the balance of …

Microdeletion and microduplication copy number variations are found in patients with autism
spectrum disorder and in a number of cases they include genes that are involved in the …

Since its discovery, Wnt signaling has been shown to be one of the most crucial
morphogens in development and during the maturation of central nervous system. Its action …

Wnts are a highly conserved family of lipid-modified glycoproteins that work as morphogens
to activate several signaling pathways, leading to remodeling of the cytoskeleton and the …

Wnts are a family of secreted proteins that regulate multiple steps of neural development
and stem cell differentiation. Two of them, Wnt1 and Wnt5a, activate distinct branches of Wnt …

Abstract The Autism Spectrum Disorder (ASD) consists of a prevalent and heterogeneous
group of neurodevelopmental diseases representing a severe burden to affected individuals …

Understanding the autistic brain and the involvement of genetic, non-genetic, and numerous
signaling pathways in the etiology and pathophysiology of autism spectrum disorder (ASD) …