The evolution of antibiotic-resistant bacteria is an ongoing and troubling development that
has increased the number of diseases and infections that risk going untreated. There is an …

Computational tools are increasingly being applied to solve the protein aggregation
problem, providing insight into amyloid structures and aggregation mechanisms. The …

Nanostructures, particularly those from peptide self-assemblies, have attracted great
attention lately due to their potential applications in nanotemplating and nanotechnology …

Elastin provides extensible tissues, including arteries and skin, with the propensity for elastic
recoil, whereas amyloid fibrils are associated with tissue-degenerative diseases, such as …

High-accuracy ab initio folding has remained an elusive objective despite decades of effort.
To explore the folding landscape of villin headpiece subdomain HP35, we conducted two …

Protein aggregation is a topic of immense interest to the scientific community due to its role
in several neurodegenerative diseases/disorders and industrial importance. Several in silico …

Congo red has been used to identify amyloid fibrils in tissues for more than 80 years and is
also a weak inhibitor to both amyloid-β fibril formation and toxicity. However, the specificity of …

Thioflavin T (ThT) is a fluorescent dye commonly used to stain amyloid plaques, but the
binding sites of this dye onto fibrils are poorly characterized. We present molecular …

Understanding the nature of the self-assembly of peptide nanostructures at the molecular
level is critical for rational design of functional bio-nanomaterials. Recent experimental …

Despite the complexity and the specificity of the amino acid code, a variety of peptides and
proteins unrelated in sequence and function exhibit a common behavior and assemble into …