Fox transcription factors: from development to disease
ML Golson, KH Kaestner - Development, 2016 - journals.biologists.com
Forkhead box (Fox) transcription factors are evolutionarily conserved in organisms ranging
from yeast to humans. They regulate diverse biological processes both during development …
from yeast to humans. They regulate diverse biological processes both during development …
Mechanisms of β-cell dedifferentiation in diabetes: recent findings and future research directions
M Bensellam, JC Jonas… - Journal of …, 2018 - joe.bioscientifica.com
Like all the cells of an organism, pancreatic β-cells originate from embryonic stem cells
through a complex cellular process termed differentiation. Differentiation involves the …
through a complex cellular process termed differentiation. Differentiation involves the …
[HTML][HTML] Pancreatic β cell dedifferentiation as a mechanism of diabetic β cell failure
Diabetes is associated with β cell failure. But it remains unclear whether the latter results
from reduced β cell number or function. FoxO1 integrates β cell proliferation with adaptive β …
from reduced β cell number or function. FoxO1 integrates β cell proliferation with adaptive β …
[HTML][HTML] Islet β cell failure in type 2 diabetes
The major focus of this Review is on the mechanisms of islet β cell failure in the
pathogenesis of obesity-associated type 2 diabetes (T2D). As this demise occurs within the …
pathogenesis of obesity-associated type 2 diabetes (T2D). As this demise occurs within the …
FoxO transcription factors in the maintenance of cellular homeostasis during aging
The FoxO family of Forkhead transcription factors functions at the interface of tumor
suppression, energy metabolism, and organismal longevity. FoxO factors are key …
suppression, energy metabolism, and organismal longevity. FoxO factors are key …
The beta cell in type 2 diabetes
AA Christensen, M Gannon - Current diabetes reports, 2019 - Springer
Abstract Purpose of Review This review summarizes the alterations in the β-cell observed in
type 2 diabetes (T2D), focusing on changes in β-cell identity and mass and changes …
type 2 diabetes (T2D), focusing on changes in β-cell identity and mass and changes …
Pdx1 and other factors that regulate pancreatic β‐cell survival
K Fujimoto, KS Polonsky - Diabetes, obesity and metabolism, 2009 - Wiley Online Library
A progressive reduction in β‐cell mass occurs in the evolution of diabetes. Thus
understanding the mechanisms responsible for this reduction in β‐cell mass is important for …
understanding the mechanisms responsible for this reduction in β‐cell mass is important for …
The role of FOXO1 in β-cell failure and type 2 diabetes mellitus
T Kitamura - Nature Reviews Endocrinology, 2013 - nature.com
Over the past two decades, insulin resistance has been considered essential to the
aetiology of type 2 diabetes mellitus (T2DM). However, insulin resistance does not lead to …
aetiology of type 2 diabetes mellitus (T2DM). However, insulin resistance does not lead to …
A gene expression network model of type 2 diabetes links cell cycle regulation in islets with diabetes susceptibility
Insulin resistance is necessary but not sufficient for the development of type 2 diabetes.
Diabetes results when pancreatic beta-cells fail to compensate for insulin resistance by …
Diabetes results when pancreatic beta-cells fail to compensate for insulin resistance by …
Minireview: thioredoxin-interacting protein: regulation and function in the pancreatic β-cell
A Shalev - Molecular endocrinology, 2014 - academic.oup.com
Pancreatic β-cells are responsible for insulin production, and loss of functional β-cell mass is
now recognized as a critical step in the pathogenesis of both type 1 and type 2 diabetes …
now recognized as a critical step in the pathogenesis of both type 1 and type 2 diabetes …