The concept of 'idiopathic'Parkinson's disease (PD) as a single entity has been challenged
with the identification of several clinical subtypes, pathogenic genes and putative causative …

Cellular quality control systems have gained much attention in recent decades. Among
these, autophagy is a natural self-preservation mechanism that continuously eliminates toxic …

Glutamate is the major excitatory neurotransmitter in the brain, and it is widely accepted to
play a role in synaptic plasticity and excitotoxic cell death. Glutamate binds to several …

Neurodegenerative diseases are devastating and incurable disorders characterized by
neuronal dysfunction. The major focus of experimental and clinical studies are conducted on …

Despite virologic suppression, people living with HIV (PLWH) remain at risk for developing
cognitive impairment, with aberrations in motor control being a predominant symptom …

The movement disorder Parkinson's disease (PD) is the second most frequently diagnosed
neurodegenerative disease, and is associated with aging, the environment, and genetic …

Abstract Phosphoenolpyruvate carboxykinase 1 (PCK1) is the rate-limiting enzyme in
gluconeogenesis. PCK1 is considered an anti-oncogene in several human cancers. In this …

Parkinson's disease (PD) is a progressive neurodegenerative disorder, whose treatment
with modern therapeutics leads to a plethora of side effects with prolonged usage …

Purpose Epidemiology research has demonstrated that magnesium (Mg) deficiency is
associated with a high incidence of Parkinson's disease (PD). It is known that the systemic …

Motor control requires a coordinated ensemble of spatiotemporally precise neural
oscillations across a distributed motor network, particularly in the beta range (15 to 30 Hz) to …