Organoid models have been used to address important questions in developmental and
cancer biology, tissue repair, advanced modelling of disease and therapies, among other …

Despite the enormous potential of nanomedicines to shape the future of medicine, their
clinical translation remains suboptimal. Translational challenges are present in every step of …

In this review, we discuss methods and advancements in fluorescence lifetime imaging
microscopy that permit measurements to be performed at faster speed and higher resolution …

Signal bias and membrane trafficking have recently emerged as important considerations in
the therapeutic targeting of the glucagon-like peptide-1 receptor (GLP-1R) in type 2 diabetes …

Mitochondrial dysfunction has long been implicated in the neurodegenerative disorder
Parkinson's disease (PD); however, it is unclear how mitochondrial impairment and α …

Fluorescence lifetime (FLT) is a robust intrinsic property and material constant of fluorescent
matter. Measuring this important physical indicator has evolved from a laboratory curiosity to …

We present a new microscope integrating super-resolved imaging using structured
illumination microscopy (SIM) with wide-field optically sectioned fluorescence lifetime …

Abstract Fluorescence Lifetime Imaging Microscopy (FLIM) is a robust tool to measure
Förster Resonance Energy Transfer (FRET) between two fluorescent proteins, mainly when …

In recent years, the advances in tissue engineering and regenerative medicine have
resulted in introduction of novel 3D tissue models, materials and methods to the regular …

We describe an open-source automated multiwell plate fluorescence lifetime imaging (FLIM)
methodology to read out Förster resonance energy transfer (FRET) between fluorescent …