Immuno-photodynamic therapy (IPDT): organic photosensitizers and their application in cancer ablation

Y Lu, W Sun, J Du, J Fan, X Peng - Jacs Au, 2023 - ACS Publications
Photosensitizer-based photodynamic therapy (PDT) has been considered as a promising
modality for fighting diverse types of cancers. PDT directly inhibits local tumors by a …

Inorganic nanoparticles as scaffolds for bioorthogonal catalysts

CM Hirschbiegel, X Zhang, R Huang, YA Cicek… - Advanced drug delivery …, 2023 - Elsevier
Bioorthogonal transition metal catalysts (TMCs) transform therapeutically inactive molecules
(pro-drugs) into active drug compounds. Inorganic nanoscaffolds protect and solubilize …

Target‐Specific Bioorthogonal Reactions for Precise Biomedical Applications

Z Liu, M Sun, W Zhang, J Ren, X Qu - Angewandte Chemie, 2023 - Wiley Online Library
Bioorthogonal chemistry is a promising toolbox for dissecting biological processes in the
native environment. Recently, bioorthogonal reactions have attracted considerable attention …

Bioorthogonal nanozymes for breast cancer imaging and therapy

X Zhang, Y Liu, J Doungchawee… - Journal of Controlled …, 2023 - Elsevier
Bioorthogonal catalysis via transition metal catalysts (TMCs) enables the generation of
therapeutics locally through chemical reactions not accessible by biological systems. This …

Beyond cisplatin: New frontiers in metallodrugs for hard-to-treat triple negative breast cancer

N Muhammad, M Hanif, P Yang - Coordination Chemistry Reviews, 2024 - Elsevier
Triple-negative breast cancer (TNBC) is the most aggressive and hard-to-treat form of breast
cancer. TNBC has a higher propensity for earlier relapse and an increased risk of metastasis …

Macrophage polarization induced by bacteria‐responsive antibiotic‐loaded Nanozymes for multidrug resistance‐bacterial infections management

X Zhu, J Guo, Y Yang, J Liu - Small, 2023 - Wiley Online Library
Inherited bacterial resistance and biofilm‐induced local immune inactivation are important
factors in the failure of antibiotics to fight against bacterial infections. Herein, antibiotic …

Biomimetic and bioorthogonal nanozymes for biomedical applications

C Keum, CM Hirschbiegel, S Chakraborty, S Jin… - Nano …, 2023 - Springer
Nanozymes mimic the function of enzymes, which drive essential intracellular chemical
reactions that govern biological processes. They efficiently generate or degrade specific …

Bioorthogonal nanozymes: an emerging strategy for disease therapy

Z Zhang, K Fan - Nanoscale, 2023 - pubs.rsc.org
Transition metal catalysts (TMCs), capable of performing bioorthogonal reactions, have
been engineered to trigger the formation of bioactive molecules in a controlled manner for …

Heptamethine cyanines in bioorthogonal chemistry

Y Liao, Y Liang, Y Huang, X Zeng, T He, J Yin - Chinese Chemical Letters, 2024 - Elsevier
Due to their excellent fluorescence properties and biological function, cyanine dyes have
been widely applied in biological imaging. Heptamethine cyanine (Cy7) dyes, as a type of …

In Cellulo Bioorthogonal Catalysis by Encapsulated AuPd Nanoalloys: Overcoming Intracellular Deactivation

B Rubio-Ruiz, AM Pérez-López, L Uson… - Nano Letters, 2023 - ACS Publications
Bioorthogonal metallocatalysis has opened up a xenobiotic route to perform nonenzymatic
catalytic transformations in living settings. Despite their promising features, most metals are …