Non-canonical Golgi-compartmentalized Gβγ signaling: mechanisms, functions, and therapeutic targets
G protein Gβγ subunits are key mediators of G protein-coupled receptor (GPCR) signaling
under physiological and pathological conditions; their inhibitors have been tested for the …
under physiological and pathological conditions; their inhibitors have been tested for the …
[HTML][HTML] Sequence-directed concentration of G protein-coupled receptors in COPII vesicles
G protein-coupled receptors (GPCRs) constitute the largest superfamily of plasma
membrane signaling proteins. However, virtually nothing is known about their recruitment to …
membrane signaling proteins. However, virtually nothing is known about their recruitment to …
[HTML][HTML] Spatiotemporal three-dimensional transport dynamics of endocytic cargos and their physical regulations in cells
Intracellular transport, regulated by complex cytoarchitectures and active driving forces, is
crucial for biomolecule translocations and relates to many cellular functions. Despite …
crucial for biomolecule translocations and relates to many cellular functions. Despite …
[HTML][HTML] The succinate receptor SUCNR1 resides at the endoplasmic reticulum and relocates to the plasma membrane in hypoxic conditions
The GPCR SUCNR1/GPR91 exerts proangiogenesis upon stimulation with the Krebs cycle
metabolite succinate. GPCR signaling depends on the surrounding environment and …
metabolite succinate. GPCR signaling depends on the surrounding environment and …
The ufmylation cascade controls COPII recruitment, anterograde transport, and sorting of nascent GPCRs at ER
Ufmylation is implicated in multiple cellular processes, but little is known about its functions
and regulation in protein trafficking. Here, we demonstrate that the genetic depletion of core …
and regulation in protein trafficking. Here, we demonstrate that the genetic depletion of core …
Segregation of nascent GPCRs in the ER-to-Golgi transport by CCHCR1 via direct interaction
X Xu, L Qiu, M Zhang, G Wu - Journal of Cell Science, 2024 - journals.biologists.com
ABSTRACT G protein-coupled receptors (GPCRs) constitute the largest superfamily of cell
surface signaling proteins that share a common structural topology. When compared with …
surface signaling proteins that share a common structural topology. When compared with …
[HTML][HTML] The olfactory receptor OR51E2 activates ERK1/2 through the Golgi-localized Gβγ-PI3Kγ-ARF1 pathway in prostate cancer cells
The olfactory receptor OR51E2 is ectopically expressed in prostate tissues and regulates
prostate cancer progression, but its function and regulation in oncogenic mitogen-activate …
prostate cancer progression, but its function and regulation in oncogenic mitogen-activate …
[HTML][HTML] Human C1orf27 protein interacts with α2A-adrenergic receptor and regulates its anterograde transport
The molecular mechanisms underlying the anterograde surface transport of G protein–
coupled receptors (GPCRs) after their synthesis in the endoplasmic reticulum (ER) are not …
coupled receptors (GPCRs) after their synthesis in the endoplasmic reticulum (ER) are not …
[HTML][HTML] Reduced Ca2+ transient amplitudes may signify increased or decreased depolarization depending on the neuromodulatory signaling pathway
A Debnath, PDE Williams, BA Bamber - Frontiers in Neuroscience, 2022 - frontiersin.org
Neuromodulators regulate neuronal excitability and bias neural circuit outputs. Optical
recording of neuronal Ca2+ transients is a powerful approach to study the impact of …
recording of neuronal Ca2+ transients is a powerful approach to study the impact of …
[HTML][HTML] Protocol to visualize and quantify the COPII concentration and anterograde transport of nascent G protein-coupled receptors
X Xu, G Wu - STAR protocols, 2024 - Elsevier
Here, we present a protocol for visualization and quantification of the recruitment of newly
synthesized G protein-coupled receptors (GPCRs) to coat protein complex II vesicles and …
synthesized G protein-coupled receptors (GPCRs) to coat protein complex II vesicles and …