Robust and efficient processes are needed to establish scientific confidence in new
approach methodologies (NAMs) if they are to be considered for regulatory applications …

Ocular in situ gels are a promising alternative to overcome drawbacks of conventional eye
drops because they associate the advantages of solutions such as accuracy and …

Earlier we created a chemical hazard database via natural language processing of dossiers
submitted to the European Chemical Agency with approximately 10 000 chemicals. We …

Alternative methods to animal use in toxicology are evolving with new advanced tools and
multilevel approaches, to answer from one side to 3Rs requirements, and on the other side …

Limitations of regulatory in vivo developmental neurotoxicity (DNT) testing and assessment
are well known, such as the 3Rs conflict, low throughput, high costs, high specific expertise …

Public data from ECHA online dossiers on 9,801 substances encompassing 326,749
experimental key studies and additional information on classification and labeling were …

A thorough understanding of which of the effects assessed in the in vivo Draize eye test are
responsible for driving UN GHS/EU CLP classification is critical for an adequate selection of …

The creation of large toxicological databases and advances in machine-learning techniques
have empowered computational approaches in toxicology. Work with these large databases …

Highlights•A guideline for the development of ophthalmic in situ gelling systems is
proposed.•Gelation, gelation kinetics and rheological characterization methods are …

There are multiple in vitro and ex vivo eye irritation and corrosion test methods that are
available as internationally harmonized test guidelines for regulatory use. Despite their …