Thyroid hormone is essential for fetal (brain) development. Plasma membrane transporters
control the intracellular bioavailability of thyroid hormone. In the past few decades, 15 …

Dysfunctions of the thyroid hormone (TH) transporting monocarboxylate transporter MCT8
lead to a complex X-linked syndrome with abnormal serum TH concentrations and …

Monocarboxylate transporter 8 (MCT8) deficiency is a rare, X-linked disorder arising from
mutations in the SLC16A2 gene and resulting from dysfunctional thyroid hormone transport …

The body temperature of mice is higher at night than during the day. We show here that
global deletion of acid-sensing ion channel 1a (ASIC1a) results in lower body temperature …

A genetic deficiency of the solute carrier monocarboxylate transporter 8 (MCT8), termed
Allan–Herndon–Dudley syndrome, is an important cause of X-linked intellectual and motor …

Inactivating mutations in the specific thyroid hormone transporter monocarboxylate
transporter 8 (MCT8) lead to an X-linked rare disease named MCT8 deficiency or Allan …

Patients with inactive thyroid hormone (TH) transporter MCT8 display intellectual disability
due to compromised central TH transport and action. As a therapeutic strategy, application of …

The zebrafish is an optimal experimental model to study thyroid hormone (TH) involvement
in vertebrate development. The use of state-of-the-art zebrafish genetic tools available for …

Abstract Objective The Allan-Herndon-Dudley syndrome (AHDS) is a severe disease
caused by dysfunctional central thyroid hormone transport due to functional loss of the …

Proper CNS myelination depends on the timed availability of thyroid hormone (TH) that
induces differentiation of oligodendrocyte precursor cells (OPCs) to mature, myelinating …