[HTML][HTML] Oxidative stress in cancer
Contingent upon concentration, reactive oxygen species (ROS) influence cancer evolution
in apparently contradictory ways, either initiating/stimulating tumorigenesis and supporting …
in apparently contradictory ways, either initiating/stimulating tumorigenesis and supporting …
Roles of F-box proteins in cancer
F-box proteins, which are the substrate-recognition subunits of SKP1–cullin 1–F-box protein
(SCF) E3 ligase complexes, have pivotal roles in multiple cellular processes through …
(SCF) E3 ligase complexes, have pivotal roles in multiple cellular processes through …
Architecture of the human interactome defines protein communities and disease networks
The physiology of a cell can be viewed as the product of thousands of proteins acting in
concert to shape the cellular response. Coordination is achieved in part through networks of …
concert to shape the cellular response. Coordination is achieved in part through networks of …
Nrf2 activation promotes lung cancer metastasis by inhibiting the degradation of Bach1
L Lignitto, SE LeBoeuf, H Homer, S Jiang, M Askenazi… - Cell, 2019 - cell.com
Approximately 30% of human lung cancers acquire mutations in either Keap1 or Nfe2l2,
resulting in the stabilization of Nrf2, the Nfe2l2 gene product, which controls oxidative …
resulting in the stabilization of Nrf2, the Nfe2l2 gene product, which controls oxidative …
Ferritinophagy via NCOA4 is required for erythropoiesis and is regulated by iron dependent HERC2-mediated proteolysis
JD Mancias, L Pontano Vaites, S Nissim, DE Biancur… - elife, 2015 - elifesciences.org
NCOA4 is a selective cargo receptor for the autophagic turnover of ferritin, a process critical
for regulation of intracellular iron bioavailability. However, how ferritinophagy flux is …
for regulation of intracellular iron bioavailability. However, how ferritinophagy flux is …
Hepatitis B virus X protein promotes degradation of SMC5/6 to enhance HBV replication
The hepatitis B virus (HBV) regulatory protein X (HBx) activates gene expression from the
HBV covalently closed circular DNA (cccDNA) genome. Interaction of HBx with the DDB1 …
HBV covalently closed circular DNA (cccDNA) genome. Interaction of HBx with the DDB1 …
[HTML][HTML] The macrophage heme-heme oxygenase-1 system and its role in inflammation
V Vijayan, FA Wagener, S Immenschuh - Biochemical pharmacology, 2018 - Elsevier
Abstract Heme oxygenase (HO)-1, the inducible isoform of the heme-degrading enzyme HO,
plays a critical role in inflammation and iron homeostasis. Regulatory functions of HO-1 are …
plays a critical role in inflammation and iron homeostasis. Regulatory functions of HO-1 are …
[HTML][HTML] Heme-mediated SPI-C induction promotes monocyte differentiation into iron-recycling macrophages
M Haldar, M Kohyama, AYL So, KC Wumesh, X Wu… - Cell, 2014 - cell.com
Splenic red pulp macrophages (RPM) degrade senescent erythrocytes and recycle heme-
associated iron. The transcription factor SPI-C is selectively expressed by RPM and is …
associated iron. The transcription factor SPI-C is selectively expressed by RPM and is …
PTEN counteracts FBXL2 to promote IP3R3- and Ca2+-mediated apoptosis limiting tumour growth
In response to environmental cues that promote IP3 (inositol 1, 4, 5-trisphosphate)
generation, IP3 receptors (IP3Rs) located on the endoplasmic reticulum allow the …
generation, IP3 receptors (IP3Rs) located on the endoplasmic reticulum allow the …
[HTML][HTML] FBXL5 regulates IRP2 stability in iron homeostasis via an oxygen-responsive [2Fe2S] cluster
H Wang, H Shi, M Rajan, ER Canarie, S Hong… - Molecular cell, 2020 - cell.com
Cellular iron homeostasis is dominated by FBXL5-mediated degradation of iron regulatory
protein 2 (IRP2), which is dependent on both iron and oxygen. However, how the physical …
protein 2 (IRP2), which is dependent on both iron and oxygen. However, how the physical …