This guideline presents recommendations for the management of patients with hereditary
gastrointestinal cancer syndromes. The initial assessment is the collection of a family history …

Serrated polyps have been recognised in the last decade as important premalignant lesions
accounting for between 15% and 30% of colorectal cancers. There is therefore a clinical …

Colorectal cancer (CRC) is the fourth most common cancer amongst men and women.
Between 3 and 6% of all CRCs are attributed to well-defined inherited syndromes, including …

Background & aims Serrated polyposis syndrome (SPS) is characterized by development of
numerous serrated lesions throughout the colorectum and increased risk of colorectal …

Serrated colorectal polyps, long considered innocent, are currently recognized as the
precursors to one-third of all colorectal cancers (CRC). Serrated polyposis syndrome (SPS) …

The polyposis syndromes have been categorized according to polyp histology and clinical
phenotype. The clinical importance of the syndromes relates to their inheritance as well as to …

Serrated polyp associated colorectal cancer (CRC) develops from an alternative mechanism
of colorectal carcinogenesis and accounts for 10-15% of all CRC. Serrated polyposis …

Hereditary polyposis syndromes are characterized by a large number and/or
histopathologically specific polyps in the gastrointestinal tract and a high risk of both …

The serrated pathway of carcinogenesis has been the subject of intense investigation over
the past 2 decades, but many gaps in our understanding still need to be resolved. Serrated …

Familial adenomatous polyposis has been the first form of inherited intestinal polyposis to be
recognized. For a long time it has been considered the main polyposis syndrome …