Antinuclear antibodies (ANAs) are a diverse group of autoantibodies that recognize nuclear
macromolecules and their complexes. ANAs represent key biomarkers in the evaluation of …

Objectives To identify factors that predict response to belimumab treatment in the phase 3
BLISS trials of autoantibody-positive systemic lupus erythematosus (SLE) and further …

Self-reactive B cells generated through V (D) J recombination in the bone marrow or through
accrual of random mutations in secondary lymphoid tissues are mostly purged or edited to …

Objectives To evaluate and compare the clinical efficacy of three biomarkers for interferon
(IFN) activity (measured directly and indirectly) and six traditional biomarkers in indicating …

CD8+ T cells play an essential role in immunity against intracellular pathogens, with
cytotoxicity being considered their major effector mechanism. However, we here …

Objective To determine the clinical value of six traditional and three IFN-related biomarkers
in monitoring disease activity (DA) in SLE. Methods Prospective longitudinal study of IFNα …

Objective Correlates of systemic lupus erythematosus (SLE) Responder Index (SRI)
response with clinical trial end points were examined using pooled data from the Study of …

Objective To examine the effects of treatment with belimumab on corticosteroid dose in
patients with systemic lupus erythematosus (SLE) over 52 weeks in 2 randomized …

Introduction Autoantibodies to cytosolic 5′-nucleotidase 1A (cN-1A; NT5C1A) have a high
specificity when differentiating sporadic inclusion body myositis from polymyositis and …

Objective. The aim of this study was to determine whether anti-nucleosome antibodies
function as activity-specific biomarkers in SLE. Methods. Fifty-one patients were recruited …