The first paper on “inflammaging” published in 2001 paved the way for a unifying theory on
how and why aging turns out to be the main risk factor for the development of the most …

HbA 1c is the most used parameter to assess glycaemic control. However, evidence
suggests that the concept of hyperglycaemia has profoundly changed and that different …

Obesity is one of the major risk factors for the development of both impaired glucose
tolerance (IGT, or prediabetes) and type 2 diabetes (T2D), and its prevalence worldwide …

Atherosclerosis is one of the main complications of diabetes involving multiple causative
factors. Dysfunction of the vascular endothelium is a hallmark of most conditions that are …

Diabetic retinopathy (DR) is a diabetic complication which affects retinal function and results
in severe loss of vision and relevant retinal diseases. Retinal vascular dysfunction caused …

As a promising new target, miR-233 may regulate oxidative stress by targeting keap1-Nrf2
system to affect the pathological process of liver injury in T2DM. Ellagic acid (EA) is versatile …

Type 2 diabetes mellitus (T2DM), accounting for 90–95% cases of diabetes, is characterized
by chronic inflammation. The mechanisms that control inflammation activation in T2DM are …

A growing body of evidence points to the role of glucose variability (GV) in the development
of the microvascular and macrovascular complications of diabetes. In this review, we …

Diabetes is one of the most relevant co-morbidity in worsening the prognosis of COVID-19
[1]. Data is also showing that hyperglycemia, in both people with or without diabetes, is an …

Imbalanced regulation of reactive oxygen species (ROS) and antioxidant factors in cells is
known as “oxidative stress (OS)”. OS regulates key cellular physiological responses through …