Targeting delivery of a novel TGF-β type I receptor-mimicking peptide to activated hepatic stellate cells for liver fibrosis therapy via inhibiting the TGF-β1/Smad and p38 …
X Liu, X Wang, L Xu, J Fan, Q Yuan, F Zhang… - European Journal of …, 2024 - Elsevier
Excessive transforming growth factor β1 (TGF-β1) secreted by activated hepatic stellate cells
(aHSCs) aggravates liver fibrosis via over-activation of TGF-β1-mediated signaling …
(aHSCs) aggravates liver fibrosis via over-activation of TGF-β1-mediated signaling …
Advances in Research on the Effectiveness and Mechanism of Active Ingredients from Traditional Chinese Medicine in Regulating Hepatic Stellate Cells Autophagy …
XY Liu, W Zhang, BF Ma, MM Sun… - Drug Design …, 2024 - Taylor & Francis
Hepatic fibrosis (HF) is a pathological process of structural and functional impairment of the
liver and is a key component in the progression of chronic liver disease. There are no …
liver and is a key component in the progression of chronic liver disease. There are no …
Protective effect of dendropanoxide against cadmium-induced hepatotoxicity via anti-inflammatory activities in Sprague-Dawley rats
Cadmium (Cd) accumulates in the body through contaminated foods or water and causes
pathological damage to the liver via oxidative stress and inflammatory reactions. This study …
pathological damage to the liver via oxidative stress and inflammatory reactions. This study …
[HTML][HTML] Dendropanoxide alleviates Thioacetamide-induced hepatic fibrosis via inhibition of ROS production and inflammation in BALB/C mice
Hepatic fibrosis results from overproduction and excessive accumulation of extracellular
matrix (ECM) proteins in hepatocytes. Although the beneficial effects of dendropanoxide …
matrix (ECM) proteins in hepatocytes. Although the beneficial effects of dendropanoxide …
Multi-omic analysis identifies the molecular mechanism of hepatocellular carcinoma with cirrhosis
M Xuan, X Gu, H Xing - Scientific Reports, 2024 - nature.com
Hepatocellular carcinoma with cirrhosis promotes the advancement of malignancy and the
development of fibrosis in normal liver tissues. Understanding the pathological mechanisms …
development of fibrosis in normal liver tissues. Understanding the pathological mechanisms …
Loureirin B ameliorates cholestatic liver fibrosis via AKT/mTOR/ATG7-mediated autophagy of hepatic stellate cells
W Cheng, X Zeng, P Cheng, J Zhang - European Journal of Pharmacology, 2024 - Elsevier
Aim of the study Chronic cholestasis leads to liver fibrosis, which lacks effective treatment. In
this study, we investigated the role and mechanisms of action of loureirin B (LB) in …
this study, we investigated the role and mechanisms of action of loureirin B (LB) in …
Fluorofenidone alleviates liver fibrosis by inhibiting hepatic stellate cell autophagy via the TGF-β1/Smad pathway: implications for liver cancer
X Peng, H Yang, L Tao, J Xiao, Y Zeng, Y Shen, X Yu… - PeerJ, 2023 - peerj.com
Objectives Liver fibrosis is a key stage in the progression of various chronic liver diseases to
cirrhosis and liver cancer, but at present, there is no effective treatment. This study …
cirrhosis and liver cancer, but at present, there is no effective treatment. This study …
Dendropanax morbifera Leveille Extract-Induced Alteration of Metabolic Profile in Whitening Effects
T Bu, D Kim, S Kim - Horticulturae, 2024 - mdpi.com
This study aimed to evaluate the potential of Dendropanax morbifera Leveille (D. morbifera)
extract as a natural melanin depigmentation agent to achieve skin whitening. Treating α …
extract as a natural melanin depigmentation agent to achieve skin whitening. Treating α …