This review outlines the development of human leukocyte antigen (HLA) antibody detection
assays and their use in organ transplantation in both antibody screening and crossmatching …

As the practice of medicine becomes more reliant on imaging and laboratory tests, medical
decisions will be increasingly based on numbers. Accordingly, following the introduction of …

Background Anti-human leukocyte antigen donor-specific antibodies (anti-HLA DSAs) are
recognized as a major barrier to patients' access to organ transplantation and the major …

Technological advances in HLA laboratory testing undoubtedly improved the sensitivity and
specificity of HLA antibody assessment but not without introducing a set of challenges …

Introduction Several studies have investigated the impact of circulating complement-
activating anti-human leukocyte antigen donor-specific antibodies (anti-HLA DSAs) on …

Background Complement-fixing antibodies against donor HLA are considered a
contraindication for kidney transplant. A modification of the IgG single-antigen bead (SAB) …

With the introduction of the virtual allocation crossmatch in the Eurotransplant (ET) region in
2023, the determination of unacceptable antigen mismatches (UAM) in kidney transplant …

Background Complement-binding donor-specific human leukocyte antigen (HLA) antibodies
in kidney recipients have been associated with a higher risk of allograft rejection and loss …

Immunoglobulin glycosylation is a pivotal mechanism that drives the diversification of
antibody functions. The composition of the IgG glycome is influenced by environmental …

The consolidation of single antigen beads (SAB-panIgG) assay in the detection of preformed
anti-human leukocyte antigen (HLA) antibodies has improved transplantation success …