Dipeptidyl-peptidase IV/CD26 (DPP IV) is a cell-surface protease belonging to the
prolyloligopeptidase family. It selectively removes the N-terminal dipeptide from peptides …

CD26/DPPIV can be considered a moonlighting protein because it is a multifunctional
protein that exerts its different functions depending on cell type and intra-or extracellular …

Abstract Dipeptidyl peptidase IV (DPP-IV/CD26) is a multifunctional type II transmembrane
serine peptidase. This enzyme contributes to the regulation of various physiological …

The costimulatory properties of CD26 have been studied extensively and significant
progress has been made in unravelling the complex nature of this molecule. Here, we …

DP (dipeptidyl peptidase) IV is the archetypal member of its six-member gene family. Four
members of this family, DPIV, FAP (fibroblast activation protein), DP8 and DP9, have a rare …

Ingestion of food results in the release of peptide hormones in the gut, termed incretins, that
regulate insulin in a glucose-dependent manner. 1 When blood glucose levels are high, the …

The role of CD26 in human T cell biology is puzzling. Despite being extensively
characterized, it has been called 'a moonlighting protein'since it has multifunctional effects …

Dipeptidyl peptidase (DPP) IV has roles in T‐cell costimulation, chemokine biology, type‐II
diabetes and tumor biology. Fibroblast activation protein (FAP) has been implicated in tumor …

The amino boronic dipeptide, PT-100 (Val-boro-Pro), a dipeptidyl peptidase (DPP) inhibitor,
has been shown to up-regulate gene expression of certain cytokines in hematopoietic tissue …

Inhibitors of the enzyme dipeptidyl peptidase IV (DPP IV) are of increasing interest to both
diabetologists and the pharmaceutical industry alike, as they may become established as …