CARM1/PRMT4: making its mark beyond its function as a transcriptional coactivator
Coactivator-associated arginine methyltransferase 1 (CARM1), identified 20 years ago as a
coregulator of transcription, is an enzyme that catalyzes arginine methylation of proteins …
coregulator of transcription, is an enzyme that catalyzes arginine methylation of proteins …
Enrichments of post‐translational modifications in proteomic studies
L Pieroni, F Iavarone, A Olianas… - Journal of separation …, 2020 - Wiley Online Library
More than 300 different protein post‐translational modifications are currently known, but only
a few have been extensively investigated because modified proteoforms are commonly …
a few have been extensively investigated because modified proteoforms are commonly …
Development of potent and selective coactivator-associated arginine methyltransferase 1 (CARM1) degraders
CARM1 is amplified or overexpressed in many cancer types, and its overexpression
correlates with poor prognosis. Potent small-molecule inhibitors for CARM1 have been …
correlates with poor prognosis. Potent small-molecule inhibitors for CARM1 have been …
Boric-Acid-Functionalized Covalent Organic Framework for Specific Enrichment and Direct Detection of cis-Diol-Containing Compounds by Matrix-Assisted Laser …
Design and synthesis of a novel matrix that serves as highly selective adsorption material
are significant for the matrix-assisted laser desorption/ionization time-of-flight mass …
are significant for the matrix-assisted laser desorption/ionization time-of-flight mass …
[HTML][HTML] Hydrophilic interaction chromatography–mass spectrometry for metabolomics and proteomics: state-of-the-art and current trends
I Kohler, M Verhoeven, R Haselberg… - Microchemical Journal, 2022 - Elsevier
Among all the–omics approaches, proteomics and metabolomics have received increased
attention over the last decade. Both approaches have reached a certain level of maturity …
attention over the last decade. Both approaches have reached a certain level of maturity …
Proteome-wide Profiling of Asymmetric Dimethylated Arginine in Human Breast Tumors
Arginine methylation catalyzed by protein arginine methyltransferases (PRMTs) is a
prevalent post-translational modification (PTM) that regulates diverse cellular processes …
prevalent post-translational modification (PTM) that regulates diverse cellular processes …
The utility of proteases in proteomics, from sequence profiling to structure and function analysis
In mass spectrometry (MS)‐based bottom‐up proteomics, protease digestion plays an
essential role in profiling both proteome sequences and post‐translational modifications …
essential role in profiling both proteome sequences and post‐translational modifications …
[HTML][HTML] Deep protein methylation profiling by combined chemical and immunoaffinity approaches reveals novel PRMT1 targets
Protein methylation has been implicated in many important biological contexts including
signaling, metabolism, and transcriptional control. Despite the importance of this post …
signaling, metabolism, and transcriptional control. Despite the importance of this post …
[HTML][HTML] Proteogenomic discovery of sORF-encoded peptides associated with bacterial virulence in Yersinia pestis
S Cao, X Liu, Y Huang, Y Yan, C Zhou, C Shao… - Communications …, 2021 - nature.com
Plague caused by Yersinia pestis is one of the deadliest diseases. However, many
molecular mechanisms of bacterial virulence remain unclear. This study engaged in the …
molecular mechanisms of bacterial virulence remain unclear. This study engaged in the …
mNeuCode Empowers Targeted Proteome Analysis of Arginine Dimethylation
Characterization of protein arginine dimethylation presents significant challenges due to its
occurrence at the substoichiometric level. To enable a targeted MS/MS analysis of these …
occurrence at the substoichiometric level. To enable a targeted MS/MS analysis of these …