Investigation of the hippocampus has historically focused on computations within the
trisynaptic circuit. However, discovery of important anatomical and functional variability …

Anxiety is of paramount importance for animals, as it allows assessment of the environment
while minimizing exposure to potential threats. Furthermore, anxiety disorders are highly …

Anxiety is a mental state characterized by an intense sense of tension, worry or
apprehension, relative to something adverse that might happen in the future. Researchers …

Importance Alzheimer disease (AD) is now known to have a long preclinical phase in which
pathophysiologic processes develop many years, even decades, before the onset of clinical …

Adult hippocampal neurogenesis is implicated in antidepressant action, stress responses,
and cognitive functioning. The hippocampus is functionally segregated along its longitudinal …

The hippocampus (HPC) has been traditionally considered to subserve mnemonic
processing and spatial cognition. Over the past decade, however, there has been increasing …

Because pain signals potential harm to the organism, it immediately attracts attention and
motivates decisions and action. However, pain is also subject to motivations—an aspect that …

Importance Maternal psychological distress during pregnancy is associated with adverse
obstetric outcomes and neuropsychiatric deficits in children. Currently unavailable in vivo …

Burning mouth syndrome (BMS) is a debilitating, idiopathic chronic pain condition. For many
BMS patients, burning oral pain begins in late morning and becomes more intense …

Overgeneralization of dangerous stimuli is a possible etiological account for anxiety
disorders, yet the underlying behavioral and neural origins remain vague. Specifically, it is …