Abstract 3D printing alias additive manufacturing can transform 3D virtual models created by
computer-aided design (CAD) into physical 3D objects in a layer-by-layer manner …

Biological signalling is regulated through a complex and tightly choreographed interplay
between cells and their extracellular matrix. The spatiotemporal control of these interactions …

Utilization of polymers as biomaterials has greatly impacted the advancement of modern
medicine. Specifically, polymeric biomaterials that are biodegradable provide the significant …

The conjugation of biomolecules can impart materials with the bioactivity necessary to
modulate specific cell behaviors. While the biological roles of particular polypeptide …

The main limitation in engineering in vitro tissues is the lack of a sufficient blood vessel
system—the vascularization. In vivo almost all tissues are supplied by these endothelial cell …

In situ, cells are highly sensitive to geometrical and mechanical constraints from their
microenvironment. These parameters are, however, uncontrolled under classic culture …

In the absence of perfusable vascular networks, three-dimensional (3D) engineered tissues
densely populated with cells quickly develop a necrotic core. Yet the lack of a general …

The interaction of cells and tissues with artificial materials designed for applications in
biotechnologies and in medicine is governed by the physical and chemical properties of the …

Abstract Poly (ethylene glycol)(PEG) hydrogels, modified with RGD, are promising platforms
for cell encapsulation and tissue engineering. While these hydrogels offer tunable …

Certain polymeric materials such as polyurethanes (PUs) are the most prevalent class of
used biomaterials in regenerative medicine and have been widely explored as vascular …