The stability of lipids and other metabolites in human body fluids ranges from very stable
over several days to very unstable within minutes after sample collection. Since the high …

Discrepant sample processing remains a significant challenge within blood metabolomics
research, introducing non-biological variation into the measured metabolome and biasing …

The emerging disciplines of lipidomics and metabolomics show great potential for the
discovery of diagnostic biomarkers, but appropriate pre-analytical sample-handling …

Objectives Lipid mediators are bioactive lipids which help regulate inflammation. We aimed
to develop an ultra-high-performance liquid chromatography-tandem mass spectrometry …

Oxaliplatin, a platinum-based chemotherapeutic drug, which is used as first-line treatment
for some types of colorectal carcinoma, causes peripheral neuropathic pain in patients. In …

Endocannabinoids (ECs), such as anandamide and 2-arachidonyl glycerol (2-AG),
contribute to the pathology of inflammatory, malignant, cardiovascular, metabolic and mental …

Background The COVID-19 pandemic challenged the management of technical and human
resources in intensive care units (ICU) across the world. Several long-term predictors for …

Monoacylglycerol lipase (MGL) expressed in cancer cells influences cancer pathogenesis
but the role of MGL in the tumor microenvironment (TME) is less known. Using a syngeneic …

We recently described that monoacylglycerol lipase (MGL) is present in the tumor
microenvironment (TME), increasing tumor growth. In this study we compare the implications …

Traumatic brain injury (TBI) is often complicated by long-lasting disabilities, including
headache, fatigue, insomnia, hyperactivity, and cognitive deficits. In a previous study in …