Carbodiimide-based synthesis of N-heterocycles: moving from two classical reactive sites to chemical bond breaking/forming reaction

Y Wang, WX Zhang, Z Xi - Chemical Society Reviews, 2020 - pubs.rsc.org
Carbodiimides are a unique class of heterocumulene compounds that display distinctive
chemical properties. The rich chemistry of carbodiimides has drawn increasing attention …

Review of synthesis of 1, 3, 4-oxadiazole derivatives

KD Patel, SM Prajapati, SN Panchal… - Synthetic …, 2014 - Taylor & Francis
Oxadiazole nucleus shows a broad spectrum of pharmaceutical applications. Thus, in recent
years scientists have developed various new methods for the synthesis of its derivatives …

[PDF][PDF] Synthesis and Biological Evaluationof Novel 1, 3, 4-Oxadiazole Derivatives as Antimicrobial Agents

PB Parekar, SD Sonwane, VN Dhakane… - Journal of …, 2023 - jcdronline.org
The major drawback of current treatment of infectious diseases are challenging due to
resistance to antimicrobial agents and their side effects. In order to overcome this situation, it …

Novel 1, 3, 4-oxadiazole motifs bearing a quinoline nucleus: synthesis, characterization and biological evaluation of their antimicrobial, antitubercular, antimalarial and …

GG Ladani, MP Patel - New Journal of Chemistry, 2015 - pubs.rsc.org
A series of quinoline based 1, 3, 4-oxadiazole derivatives (8a–l) were synthesized by a
chloro-amine coupling reaction approach with different catalysts and solvents. Substituted 1 …

Design, synthesis, in vitro and in silico evaluation of novel substituted 1, 2, 4-triazole analogues as dual human VEGFR-2 and TB-InhA inhibitors

AG Zawal, MM Abdel-Aziz, MH Elbatreek… - Bioorganic …, 2023 - Elsevier
Cancer is a leading cause of death globally and has been associated with Mycobacterium
tuberculosis (Mtb). The angiogenesis-related VEGFR-2 is a common target between cancer …

Design and synthesis of novel 1, 3, 4‐oxadiazole based azaspirocycles catalyzed by NaI under mild condition and evaluated their antidiabetic and antibacterial …

AJ Radia, JN Lalpara, IJ Modasiya… - Journal of Heterocyclic …, 2021 - Wiley Online Library
A modest, efficient, and mild synthetic procedure has been developed for the synthesis of
novel series of 1, 3, 4‐oxadiazole containing azaspirocycles derivatives. The reaction of 1, 3 …

Design and Rapid Microwave Irradiated One-Pot Synthesis of Tetrahydropyrimidine Derivatives and Their Screening In Vitro Antidiabetic Activity

JN Lalpara, SD Hadiyal, AJ Radia… - Polycyclic Aromatic …, 2022 - Taylor & Francis
A rapid and efficient method has been developed for one-pot synthesis of some newly
designed tetrahydropyrimidine derivatives with aid of 1, 3, 4-oxadiazole containing …

Tribromoisocyanuric acid as an alternative oxidant in the synthesis of 2-amino-1, 3, 4-oxadiazoles from 1-acylthiosemicarbazides

J Crispim-Neto, MCS de Mattos - Tetrahedron Letters, 2023 - Elsevier
A simple, efficient, and environmentally benign approach has been developed for
conversion of 1-acylthiosemicarbazides into 2-amino-1, 3, 4-oxadiazoles by the reaction …

[PDF][PDF] Recent advances on oxadiazole motifs: Synthesis, reactions and biological activities

OO Ajani, KT Iyaye - Mediterr. J. Chem, 2020 - pdfs.semanticscholar.org
Abstract: 1, 3, 4-oxadiazole derivatives have shown to have diverse and vast applications,
from medicinal chemistry for the treatment and possible treatment of various ailments to its …

A KHSO4 mediated facile synthesis of 2-amino-1, 3, 4-oxadiazole derivatives

B Long, B Tian, Q Tang, X Hu, L Han, Z Wang, C Wang… - Tetrahedron, 2021 - Elsevier
A novel, efficient and mild KHSO 4 mediated synthesis for 2-amino-1, 3, 4-oxadiazoles has
been established via the cyclodesulfurization of benzoylhydrazine and isothiocyanate …