Background: Preclinical studies, clinical trials, and reviews suggest increasing 3', 5'-cyclic
adenosine monophosphate (cAMP) and 3', 5'-cyclic guanosine monophosphate (cGMP) with …

Activity-driven transcription is a key event associated with long-lasting forms of neuronal
plasticity. Despite the efforts to investigate the regulatory mechanisms that control this …

It remains unknown what causes inflammatory bowel disease (IBD), including signaling
networks perpetuating chronic gastrointestinal inflammation in Crohn's disease (CD) and …

Induced CREB activity is a hallmark of long-term memory, but the full repertoire of CREB
transcriptional targets required specifically for memory is not known in any system. To obtain …

Cisplatin resistance is one of the main causes of treatment failure and death in head and
neck squamous cell carcinoma (HNSCC). A more comprehensive understanding of the …

Oxidative stress and neuroinflammation have been deeply associated with Alzheimer's
disease. DL0410 is a novel acetylcholinesterase inhibitor with potential anti-oxidative effects …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease, which is still
missing effective therapeutic strategies. Although manipulation of neuronal excitability has …

Status epilepticus (SE) is a life-threatening condition that can give rise to a number of
neurological disorders, including learning deficits, depression and epilepsy. Many of the …

Brain-derived neurotrophic factor (BDNF) signals through its high affinity receptor
Tropomyosin receptor kinase-B (TrkB) to regulate neuronal development, synapse formation …

The nucleolus serves as a principal site of ribosome biogenesis but is also implicated in
various non-ribosomal functions, including negative regulation of the pro-apoptotic …