Tissue engineered bone using select growth factors: a comprehensive review of animal studies and clinical translation studies in man

D Gothard, EL Smith, JM Kanczler… - European cells & …, 2014 - eprints.soton.ac.uk
There is a growing socio-economic need for effective strategies to repair damaged bone
resulting from disease, trauma and surgical intervention. Bone tissue engineering has …

BMP-2 gene delivery-based bone regeneration in dentistry

SY Park, KH Kim, S Kim, YM Lee, YJ Seol - Pharmaceutics, 2019 - mdpi.com
Bone morphogenetic protein-2 (BMP-2) is a potent growth factor affecting bone formation.
While recombinant human BMP-2 (rhBMP-2) has been commercially available in cases of …

3D printed calcium phosphate scaffolds with controlled release of osteogenic drugs for bone regeneration

H Sun, C Zhang, B Zhang, P Song, X Xu, X Gui… - Chemical Engineering …, 2022 - Elsevier
The purpose of this research was to repair critical size defects of a skull. First, the CT data on
the Beagle's skull were used to reconstruct an implant model. Then two Ф15 mm critical …

Baculovirus: an insect-derived vector for diverse gene transfer applications

KJ Airenne, YC Hu, TA Kost, RH Smith, RM Kotin… - Molecular Therapy, 2013 - cell.com
Insect-derived baculoviruses have emerged as versatile and safe workhorses of
biotechnology. Baculovirus expression vectors (BEVs) have been applied widely for crop …

Mesoporous bioactive glass nanolayer-functionalized 3D-printed scaffolds for accelerating osteogenesis and angiogenesis

Y Zhang, L Xia, D Zhai, M Shi, Y Luo, C Feng, B Fang… - Nanoscale, 2015 - pubs.rsc.org
The hierarchical microstructure, surface and interface of biomaterials are important factors
influencing their bioactivity. Porous bioceramic scaffolds have been widely used for bone …

Imaging strategies for tissue engineering applications

SY Nam, LM Ricles, LJ Suggs… - Tissue Engineering Part …, 2015 - liebertpub.com
Tissue engineering has evolved with multifaceted research being conducted using
advanced technologies, and it is progressing toward clinical applications. As tissue …

MicroRNA delivery for regenerative medicine

B Peng, Y Chen, KW Leong - Advanced drug delivery reviews, 2015 - Elsevier
MicroRNA (miRNA) directs post-transcriptional regulation of a network of genes by targeting
mRNA. Although relatively recent in development, many miRNAs direct differentiation of …

Graphene-oxide-modified β-tricalcium phosphate bioceramics stimulate in vitro and in vivo osteogenesis

C Wu, L Xia, P Han, M Xu, B Fang, J Wang, J Chang… - Carbon, 2015 - Elsevier
Graphene oxide (GO) has attracted much interest for applications in bone tissue
engineering; however, until now, the interaction between GO and stem cells, and the in vivo …

Osteogenic differentiation of adipose-derived stem cells and calvarial defect repair using baculovirus-mediated co-expression of BMP-2 and miR-148b

YH Liao, YH Chang, LY Sung, KC Li, CL Yeh, TC Yen… - Biomaterials, 2014 - Elsevier
Repair of large calvarial bony defect remains a challenge for orthopedic surgeons. Since
microRNAs (miRNAs) modulate the osteogenesis of osteoprogenitor cells, we aimed to …

Bone regeneration in calvarial defects in a rat model by implantation of human bone marrow-derived mesenchymal stromal cell spheroids

H Suenaga, KS Furukawa, Y Suzuki, T Takato… - Journal of Materials …, 2015 - Springer
Mesenchymal stem cell (MSC) condensation contributes to membrane ossification by
enhancing their osteodifferentiation. We investigated bone regeneration in rats using the …