The human ether-à-go-go-related gene (hERG) K+ channel plays an important role in
cardiac action potentials. The inhibition of the hERG channel may lead to long QT syndrome …

Protein transporters not only have essential functions in regulating the transport of
endogenous substrates and remote communication between organs and organisms, but …

Drug addiction is a global public health crisis, and the design of antiaddiction drugs remains
a major challenge due to intricate mechanisms. Since experimental drug screening and …

Cocaine addiction is a psychosocial disorder induced by the chronic use of cocaine and
causes a large number of deaths around the world. Despite decades of effort, no drugs have …

No anti-cocaine addiction drugs have been approved by the Food and Drug Administration
despite decades of effort. The main challenge is the intricate molecular mechanisms of …

Currently, there are no FDA-approved medications for the treatment of psychostimulant use
disorders (PSUD). We have previously discovered “atypical” dopamine transporter (DAT) …

Pharmacological blockade of the I Kr channel (hERG) by diverse drugs in clinical use is
associated with the Long QT Syndrome that can lead to life threatening arrhythmia. Various …

Dopamine transporters (DAT) are transmembrane proteins that translocate dopamine from
the extracellular space into presynaptic neurons. We aimed to investigate the predictive …

Despite being the most widely prescribed and misused type of medication, opioids continue
to function as robust pain relief agents; however, overdosing is a significant cause of …

Drug misuse is a significant social and public health problem worldwide. Misused
substances exert their neurobehavioural effects through changing neural signalling within …