Mechanisms of vascular aging

Z Ungvari, S Tarantini, AJ Donato, V Galvan… - Circulation …, 2018 - Am Heart Assoc
Aging of the vasculature plays a central role in morbidity and mortality of older people. To
develop novel treatments for amelioration of unsuccessful vascular aging and prevention of …

Genetics of thoracic and abdominal aortic diseases: aneurysms, dissections, and ruptures

A Pinard, GT Jones, DM Milewicz - Circulation research, 2019 - Am Heart Assoc
Dissections or ruptures of aortic aneurysms remain a leading cause of death in the
developed world, with the majority of deaths being preventable if individuals at risk are …

[HTML][HTML] The Society for Vascular Surgery practice guidelines on the care of patients with an abdominal aortic aneurysm

EL Chaikof, RL Dalman, MK Eskandari… - Journal of vascular …, 2018 - Elsevier
Background Decision-making related to the care of patients with an abdominal aortic
aneurysm (AAA) is complex. Aneurysms present with varying risks of rupture, and patient …

Mechanisms of Vascular Aging, A Geroscience Perspective: JACC Focus Seminar

Z Ungvari, S Tarantini, F Sorond, B Merkely… - Journal of the American …, 2020 - jacc.org
Age-related pathological alterations of the vasculature have a critical role in morbidity and
mortality of older adults. In epidemiological studies, age is the single most important …

Understanding the pathogenesis of abdominal aortic aneurysms

H Kuivaniemi, EJ Ryer, JR Elmore… - Expert review of …, 2015 - Taylor & Francis
An aortic aneurysm is a dilatation in which the aortic diameter is≥ 3.0 cm. If left untreated,
the aortic wall continues to weaken and becomes unable to withstand the forces of the …

[HTML][HTML] Risk factors for abdominal aortic aneurysm in population-based studies: a systematic review and meta-analysis

E Altobelli, L Rapacchietta, VF Profeta… - International journal of …, 2018 - mdpi.com
Abdominal aortic aneurysm (AAA) represents an important public health problem with a
prevalence between 1.3% and 12.5%. Several population-based randomized trials have …

Inhibition of macrophage histone demethylase JMJD3 protects against abdominal aortic aneurysms

FM Davis, LC Tsoi, WJ Melvin, A DenDekker… - Journal of Experimental …, 2021 - rupress.org
Abdominal aortic aneurysms (AAAs) are a life-threatening disease for which there is a lack
of effective therapy preventing aortic rupture. During AAA formation, pathological vascular …

[HTML][HTML] The care of patients with an abdominal aortic aneurysm: the Society for Vascular Surgery practice guidelines

EL Chaikof, DC Brewster, RL Dalman… - Journal of vascular …, 2009 - jvascsurg.org
The Clinical Practice Council of the Society for Vascular Surgery charged a writing
committee with the task of updating practice guidelines, initally published in 2003, for …

[HTML][HTML] Genetic and epigenetic mechanisms underlying vascular smooth muscle cell phenotypic modulation in abdominal aortic aneurysm

R Gurung, AM Choong, CC Woo, R Foo… - International journal of …, 2020 - mdpi.com
Abdominal aortic aneurysm (AAA) refers to the localized dilatation of the infra-renal aorta, in
which the diameter exceeds 3.0 cm. Loss of vascular smooth muscle cells, degradation of …

[HTML][HTML] Abdominal aortic aneurysm formation with a focus on vascular smooth muscle cells

G Qian, O Adeyanju, A Olajuyin, X Guo - Life, 2022 - mdpi.com
Abdominal aortic aneurysm (AAA) is a lethal degenerative vascular disease that affects,
mostly, the elder population, with a high mortality rate (> 80%) upon rupture. It features a …