A new definition of poststroke spasticity and the interference of spasticity with motor recovery from acute to chronic stages

S Li, GE Francisco, WZ Rymer - … and Neural Repair, 2021 - journals.sagepub.com
The relationship of poststroke spasticity and motor recovery can be confusing.“True” motor
recovery refers to return of motor behaviors to prestroke state with the same end-effectors …

Brainstem circuits controlling action diversification

L Ruder, S Arber - Annual review of neuroscience, 2019 - annualreviews.org
Neuronal circuits that regulate movement are distributed throughout the nervous system.
The brainstem is an important interface between upper motor centers involved in action …

A unifying pathophysiological account for post-stroke spasticity and disordered motor control

S Li, YT Chen, GE Francisco, P Zhou… - Frontiers in …, 2019 - frontiersin.org
Cortical and subcortical plastic reorganization occurs in the course of motor recovery after
stroke. It is largely accepted that plasticity of ipsilesional motor cortex primarily contributes to …

Extensive cortical convergence to primate reticulospinal pathways

KM Fisher, B Zaaimi, SA Edgley… - Journal of …, 2021 - Soc Neuroscience
Early evolution of the motor cortex included development of connections to brainstem
reticulospinal neurons; these projections persist in primates. In this study, we examined the …

Premotor cortical-cerebellar reorganization in a macaque model of primary motor cortical lesion and recovery

T Yamamoto, T Hayashi, Y Murata, T Ose… - Journal of …, 2019 - Soc Neuroscience
Neuromotor systems have the capacity for functional recovery following local damage. The
literature suggests a possible role for the premotor cortex and cerebellum in motor recovery …

Recovery after spinal cord injury is enhanced by anti-Nogo-A antibody therapy—from animal models to clinical trials

AM Sartori, AS Hofer, ME Schwab - Current Opinion in Physiology, 2020 - Elsevier
The ability of the central nervous system to regenerate over long distances after a lesion is
restricted by the presence of physical and biochemical barriers, neuronal growth programs …

Loss of motor cortical inputs to the red nucleus after CNS disorders in nonhuman primates

S Borgognon, EM Rouiller - Journal of Neuroscience, 2023 - Soc Neuroscience
The premotor (PM) and primary motor (M1) cortical areas broadcast voluntary motor
commands through multiple neuronal pathways, including the corticorubral projection that …

The unsolved role of heightened connectivity from the unaffected hemisphere to paretic arm muscles in chronic stroke

U Hammerbeck, D Hoad, R Greenwood… - Clinical …, 2019 - Elsevier
Objective Ipsilateral connectivity from the non-stroke hemisphere to paretic arm muscles
appears to play little role in functional recovery, which instead depends on contralateral …

Functional near-infrared-spectroscopy-based measurement of changes in cortical activity in macaques during post-infarct recovery of manual dexterity

J Kato, T Yamada, H Kawaguchi, K Matsuda… - Scientific Reports, 2020 - nature.com
Because compensatory changes in brain activity underlie functional recovery after brain
damage, monitoring of these changes will help to improve rehabilitation effectiveness …

Cortical projection from the premotor or primary motor cortex to the subthalamic nucleus in intact and parkinsonian adult macaque monkeys: a pilot tracing study

S Borgognon, J Cottet, S Badoud, J Bloch… - Frontiers in neural …, 2020 - frontiersin.org
Besides the main cortical inputs to the basal ganglia, via the corticostriatal projection, there
is another input via the corticosubthalamic projection (CSTP), terminating in the subthalamic …