The ability of cells to divide asymmetrically is essential for generating diverse cell types
during development. The past 10 years have seen tremendous progress in our …

Cell polarity, the generation of cellular asymmetries, is necessary for diverse processes in
animal cells, such as cell migration, asymmetric cell division, epithelial barrier function, and …

Cell division is commonly thought to involve the equal distribution of cellular components
into the two daughter cells. During many cell divisions, however, proteins, membrane …

Asymmetric cell division is fundamental for generating diversity in multicellular organisms.
The mechanisms that govern asymmetric cell division are increasingly well understood …

In the Caenorhabditis elegans zygote, a conserved network of partitioning-defective (PAR)
polarity proteins segregates into an anterior and a posterior domain, facilitated by flows of …

Polarity establishment, asymmetric division, and acquisition of cell fates are critical steps
during earlydevelopment. In this review, we discuss processes that set up the embryonic …

Centrosomes—as well as the related spindle pole bodies (SPBs) of yeast—have been
extensively studied from the perspective of their microtubule-organizing roles. Moreover, the …

A hallmark of polarized cells is the segregation of the PAR polarity regulators into
asymmetric domains at the cell cortex,. Antagonistic interactions involving two conserved …

Crosstalk between the actin cytoskeleton and microtubules promotes symmetry break to
polarize cells for division, shape changes, and migration. These cellular events are crucial …

Cell polarity is essential for cells to divide asymmetrically, form spatially restricted
subcellular structures and participate in three-dimensional multicellular organization. PAR …