Elevated levels of Th17 cells and Th17-related cytokines are associated with disease activity in patients with inflammatory bowel disease

W Jiang, J Su, X Zhang, X Cheng, J Zhou, R Shi… - Inflammation …, 2014 - Springer
Abstract Objective Interleukin-17 (IL-17)-producing T helper (Th) 17 cells are considered as
a new subset of cells critical to the development of inflammatory bowel disease (IBD). We …

Ulcerative colitis: pathogenesis

W Fries, S Comunale - Current drug targets, 2011 - ingentaconnect.com
The pathogenesis of ulcerative is still poorly understood. With the introduction of new culture-
independent techniques the research on the intestinal microbiota has revealed an important …

Ectopic tertiary lymphoid tissue in inflammatory bowel disease: protective or provocateur?

EN McNamee, J Rivera-Nieves - Frontiers in immunology, 2016 - frontiersin.org
Organized lymphoid tissues like the thymus first appeared in jawed vertebrates around 500
million years ago and have evolved to equip the host with a network of specialized sites …

Interleukin-21-producing HIV-1-specific CD8 T cells are preferentially seen in elite controllers

LTD Williams, A Bansal, S Sabbaj, SL Heath… - Journal of …, 2011 - Am Soc Microbiol
ABSTRACT A hallmark of human immunodeficiency virus type 1 (HIV-1) pathogenesis is the
rapid loss of CD4 T cells leading to generalized immune dysfunction, including an …

[HTML][HTML] Interleukin-21 triggers effector cell responses in the gut

D De Nitto, M Sarra, F Pallone… - World journal of …, 2010 - ncbi.nlm.nih.gov
In the gut of patients with Crohn's disease and patients with ulcerative colitis, the major forms
of inflammatory bowel diseases (IBD) in humans, the tissue-damaging immune response is …

Elevated IL-6 and IL-22 in early pregnancy are associated with worse disease course in women with inflammatory bowel disease

RY Wu, K Xiao, N Hotte, P Tandon, Y Elloumi… - International Journal of …, 2022 - mdpi.com
Inflammatory bowel diseases (IBD), including Ulcerative Colitis (UC) and Crohn's disease
(CD), are inflammatory conditions of the intestinal tract that affect women in their …

[HTML][HTML] Paradoxical role of Breg-inducing cytokines in autoimmune diseases

FNM Jaya, SG Garcia, FE Borràs, GCF Chan… - Journal of Translational …, 2019 - Elsevier
Regulatory B cells (Breg) are crucial immunoregulators that maintain peripheral tolerance
and suppress inflammatory autoimmune responses. In recent years, our understanding on …

From inflammatory bowel disease to colorectal cancer: what's the role of miRNAs?

M Vaghari-Tabari, N Targhazeh, S Moein… - Cancer Cell …, 2022 - Springer
Abstract Inflammatory Bowel Disease (IBD) is a chronic inflammatory disease with relapse
and remission periods. Ulcerative colitis and Crohn's disease are two major forms of the …

Multigene Analysis Unveils Distinctive Expression Profiles of Helper T-cell–related Genes in the Intestinal Mucosa that Discriminate Between Ulcerative Colitis and …

Y Iboshi, K Nakamura, E Ihara, T Iwasa… - Inflammatory bowel …, 2014 - academic.oup.com
Background Although the involvement of helper T (Th) and regulatory T (Treg) cell-related
immune molecules in pathogenesis of inflammatory bowel disease (IBD) is widely accepted …

Mucosal interleukin‐8 expression as a predictor of subsequent relapse in ulcerative colitis patients with Mayo endoscopic subscore 0

K Uchiyama, T Takagi, K Mizushima… - Journal of …, 2022 - Wiley Online Library
Abstract Background and Aim Complete endoscopic mucosal healing is defined as a Mayo
endoscopic subscore of 0. Some patients diagnosed with a Mayo endoscopic subscore 0 …