Lens, an avascular tissue involved in light transmission, generates an internal
microcirculatory system to promote ion and fluid circulation, thus providing nutrients to …

In vitro differentiation of human pluripotent stem cells (hPSCs) into specialized tissues and
organs represents a powerful approach to gain insight into those cellular and molecular …

Epithelial cells and differentiated fiber cells represent distinct compartments in the ocular
lens. While previous studies have revealed proteins that are preferentially expressed in …

Connexin (Cx)-forming channels play essential roles in maintaining lens homeostasis and
transparency. We showed here channel-independent roles of Cx50 in cell–cell adhesion …

Elucidation of both the molecular composition and organization of the ocular lens is a
prerequisite to understand its development, function, pathology, regenerative capacity, as …

Charged multivesicular-body protein 4b (CHMP4B) is a core sub-unit of the endosomal
sorting complex required for transport-III (ESCRT-III) machinery that serves myriad …

Tissue development and regeneration involve high-ordered morphogenetic processes that
are governed by elements of the cytoskeleton in conjunction with cell adhesion molecules …

Purpose: Connexins and aquaporins play essential roles in maintaining lens homeostasis
and transparency and there is a close physical and functional relationship between these …

The lens has been considered to be an immune privileged site not susceptible to the
immune processes normally associated with tissue injury and wound repair. However, as …

During accommodation, the lens changes focus by altering its shape following contraction
and relaxation of the ciliary muscle. At the cellular level, these changes in shape may be …