In accordance with the comorbidity-inflammation paradigm, comorbidities and especially
metabolic comorbidities are presumed to drive development and severity of heart failure with …

The clinical syndrome comprising heart failure (HF) symptoms but with a left ventricular
ejection fraction (EF) that is not diminished, eg, HF with preserved EF, is increasingly the …

Background—The purpose of this study was to determine whether patients with heart failure
and a preserved ejection fraction (HFpEF) have an increase in passive myocardial stiffness …

Cardiac and skeletal striated muscles are intricately designed machines responsible for
muscle contraction. Coordination of the basic contractile unit, the sarcomere, and the …

The management of heart failure with reduced ejection fraction (HF-REF) has improved
significantly over the last two decades. In contrast, little or no progress has been made in …

The giant protein titin forms a unique filament network in cardiomyocytes, which engages in
both mechanical and signaling functions of the heart. TTN, which encodes titin, is also a …

The thin and thick filaments of muscle sarcomeres are interconnected by the giant protein
titin, which is a scaffolding filament, signaling platform, and provider of passive tension and …

Background—Obesity and diabetes mellitus are important metabolic risk factors and
frequent comorbidities in heart failure with preserved ejection fraction. They contribute to …

Troponin complex is a component of skeletal and cardiac muscle thin filaments. It consists of
three subunits—troponin I, T, and C, and it plays a crucial role in muscle activity, connecting …

Left ventricular (LV) hypertrophy (LVH) is a growth in left myocardial mass mainly caused by
increased cardiomyocyte size. LVH can be a physiological adaptation to physical exercise …