Advances in genomics, proteomics and molecular pathology have generated many
candidate biomarkers with potential clinical value. Their use for cancer staging and …

MicroRNAs (miRs) are small noncoding RNAs that negatively regulate gene expression by
binding to the three untranslated regions of their target mRNAs. Deregulations of miRs were …

Systemic inflammatory events and localized disease, mediated by the microbiome, may be
measured in saliva as head and neck squamous cell carcinoma (HNSCC) diagnostic and …

Bladder cancer is the fourth most common cancer and ranks eighth as a cause of death from
cancer among men in the United States. Although guidelines assist in treatment, the art of …

Abstract Changes in DNA copy number contribute to cancer pathogenesis. We now show
that high-density single nucleotide polymorphism (SNP) arrays can detect copy number …

Among the many benefits of the Human Genome Project are new and powerful tools such as
the genome-wide hybridization devices referred to as microarrays. Initially designed to …

Rhabdomyosarcoma (RMS) in children occurs as two major histological subtypes,
embryonal (ERMS) and alveolar (ARMS). ERMS is associated with an 11p15. 5 loss of …

Endometriosis is a frequent disorder that commonly presents with infertility and pelvic pain.
Although the precise aetiology of endometriosis is unclear, it is generally considered to …

Cancer of the bladder shows divergent clinical behaviour following diagnosis and it has
been proposed that two major groups of tumours exist that develop via different molecular …

Background: The noninvasive identification of bladder tumors may improve disease control
and prevent disease progression. Aberrant promoter methylation (ie, hypermethylation) is a …