AmpC β-lactamases are clinically important cephalosporinases encoded on the
chromosomes of many of the Enterobacteriaceae and a few other organisms, where they …

Abstract β-lactams have a long history in the treatment of infectious diseases, though their
use has been and continues to be confounded by the development of resistance in target …

Pseudomonas putida is a microbial chassis of huge potential for industrial and
environmental biotechnology, owing to its remarkable metabolic versatility and ability to …

AmpC β-lactamases have been a target of study since the late 1970s. Most of these
enzymes are cephalosporinases but are capable of hydrolysing all β-lactams to some …

Enterobacter cloacae starred different pioneer studies that enabled the development of a
widely accepted model for the peptidoglycan metabolism-linked regulation of intrinsic class …

We previously described Salmonella enterica serovar Heidelberg isolates harboring a
chromosomal gene cluster similar to the glutathione S-transferase gene, a putative fosA …

The increasing spread of plasmid-borne ampC-ampR operons is of considerable medical
importance, since the AmpC β-lactamases they encode confer high level resistance to many …

The secretion of antimicrobial compounds is an ancient mechanism with clear survival
benefits for microbes competing with other microorganisms. Consequently, mechanisms that …

Mutations within the structural gene of ampD can lead to AmpC overproduction and
increases in β-lactam MICs in organisms with an inducible ampC. However, identification of …

Salmonella is the leading cause of known food-borne bacterial infections in the United
States, with an incidence rate of approximately 15 cases per 100,000 people. The rise of …