Characterizing deformability and surface friction of cancer cells

S Byun, S Son, D Amodei, N Cermak… - Proceedings of the …, 2013 - National Acad Sciences
Metastasis requires the penetration of cancer cells through tight spaces, which is mediated
by the physical properties of the cells as well as their interactions with the confined …

A new dimensionless index for evaluating cell stiffness-based deformability in microchannel

CHD Tsai, S Sakuma, F Arai… - IEEE transactions on …, 2014 - ieeexplore.ieee.org
This paper proposes a new index for evaluating the stiffness-based deformability of a cell
using a microchannel. In conventional approaches, the transit time of a cell through a …

An on-chip RBC deformability checker significantly improves velocity-deformation correlation

CHD Tsai, J Tanaka, M Kaneko, M Horade, H Ito… - Micromachines, 2016 - mdpi.com
An on-chip deformability checker is proposed to improve the velocity–deformation
correlation for red blood cell (RBC) evaluation. RBC deformability has been found related to …

Photocell-Based Optofluidic Device for Clogging-Free Cell Transit Time Measurements

F Storti, S Bonfadini, G Bondelli, V Vurro, G Lanzani… - Biosensors, 2024 - mdpi.com
Measuring the transit time of a cell forced through a bottleneck is one of the most widely
used techniques for the study of cell deformability in flow. It in turn provides an accessible …

Automated cell mechanical characterization by on-chip sequential squeezing: from static to dynamic

P Li, X Liu, M Kojima, Q Huang, T Arai - Langmuir, 2021 - ACS Publications
The mechanical properties of cells are harmless biomarkers for cell identification and
disease diagnosis. Although many systems have been developed to evaluate the static …

Actin-based biomechanical features of suspended normal and cancer cells

SMA Haghparast, T Kihara, Y Shimizu, S Yuba… - Journal of bioscience …, 2013 - Elsevier
The mechanical features of individual cells have been regarded as unique indicators of their
states, which could constantly change in accordance with cellular events and diseases …

[HTML][HTML] High resolution cell positioning based on a flow reduction mechanism for enhancing deformability mapping

S Sakuma, K Kuroda, F Arai, T Taniguchi, T Ohtani… - Micromachines, 2014 - mdpi.com
The dispersion of cell deformability mapping is affected not only by the resolution of the
sensing system, but also by cell deformability itself. In order to extract the pure deformability …

Catch, load and launch toward on-chip active cell evaluation

R Murakami, CHD Tsai, H Ito, M Tanaka… - … on Robotics and …, 2016 - ieeexplore.ieee.org
An automatic system for evaluating single cell viscoelasticity is proposed and tested in this
paper. The system includes three main operations, and they are the operations of catch …

Development of the 3D measurement system in real-time for micro-manipulation

K Ohara, M Kojima, S Takagi, M Horade… - … on Mechatronics and …, 2017 - ieeexplore.ieee.org
Construction of an activated three-dimensional (3D) tissue at outside of the human body is
desired, and expectations about the micro-manipulation to construct a 3D organization is …

Real-time precise 3D measurement of micro transparent objects using All-In-Focus imaging system

CN Nguyen, K Ohara, E Avci, T Takubo, Y Mae… - Journal of Micro-Nano …, 2012 - Springer
Recently micromanipulation has gained much interest for industrial and biological
applications. To realize efficient manipulation of these applications, it is crucial to know the …