[HTML][HTML] Cancer-associated fibroblasts in desmoplastic tumors: emerging role of integrins
The tumor microenvironment (TME) is a complex meshwork of extracellular matrix (ECM)
macromolecules filled with a collection of cells including cancer-associated fibroblasts …
macromolecules filled with a collection of cells including cancer-associated fibroblasts …
The extracellular matrix and pancreatic cancer: a complex relationship
M Weniger, KC Honselmann, AS Liss - Cancers, 2018 - mdpi.com
Pancreatic ductal adenocarcinoma (PDAC) has an extraordinarily dense fibrotic stroma that
impedes tumor perfusion and delivery of anticancer drugs. Since the extracellular matrix …
impedes tumor perfusion and delivery of anticancer drugs. Since the extracellular matrix …
The molecular interaction of collagen with cell receptors for biological function
J Elango, C Hou, B Bao, S Wang… - Polymers, 2022 - mdpi.com
Collagen, an extracellular protein, covers the entire human body and has several important
biological functions in normal physiology. Recently, collagen from non-human sources has …
biological functions in normal physiology. Recently, collagen from non-human sources has …
The charming world of the extracellular matrix: a dynamic and protective network of the intestinal wall
The intestinal extracellular matrix (ECM) represents a complex network of proteins that not
only forms a support structure for resident cells but also interacts closely with them by …
only forms a support structure for resident cells but also interacts closely with them by …
The PDAC extracellular matrix: a review of the ECM protein composition, tumor cell interaction, and therapeutic strategies
Pancreatic ductal adenocarcinoma (PDAC) is notorious for a dense fibrotic stroma that is
interlaced with a collagen-based extracellular matrix (ECM) that plays an important role in …
interlaced with a collagen-based extracellular matrix (ECM) that plays an important role in …
The integrin–collagen connection–a glue for tissue repair?
C Zeltz, D Gullberg - Journal of cell science, 2016 - journals.biologists.com
ABSTRACT The α1β1, α2β1, α10β1 and α11β1 integrins constitute a subset of the integrin
family with affinity for GFOGER-like sequences in collagens. Integrins α1β1 and α2β1 were …
family with affinity for GFOGER-like sequences in collagens. Integrins α1β1 and α2β1 were …
Reciprocal interplay between fibrillar collagens and collagen-binding integrins: implications in cancer progression and metastasis
Cancers are complex ecosystems composed of malignant cells embedded in an intricate
microenvironment made of different non-transformed cell types and extracellular matrix …
microenvironment made of different non-transformed cell types and extracellular matrix …
PROLIDASE: A Review from Discovery to its Role in Health and Disease
I Eni-Aganga, ZM Lanaghan… - Frontiers in Molecular …, 2021 - frontiersin.org
Prolidase (peptidase D), encoded by the PEPD gene, is a ubiquitously expressed cytosolic
metalloproteinase, the only enzyme capable of cleaving imidodipeptides containing C …
metalloproteinase, the only enzyme capable of cleaving imidodipeptides containing C …
Integrin α11β1 regulates cancer stromal stiffness and promotes tumorigenicity and metastasis in non-small cell lung cancer
Integrin α11β1 is a stromal cell-specific receptor for fibrillar collagens and is overexpressed
in carcinoma-associated fibroblasts (CAFs). We have investigated its direct role in cancer …
in carcinoma-associated fibroblasts (CAFs). We have investigated its direct role in cancer …
Mechanochemistry of collagen
SM Siadat, JW Ruberti - Acta Biomaterialia, 2023 - Elsevier
The collagen molecular family is the result of nearly one billion years of evolution. It is a
unique family of proteins, the majority of which provide general mechanical support to …
unique family of proteins, the majority of which provide general mechanical support to …