Rare-earth (RE) doped nanoparticles show unique features of photon conversion from an
incident wavelength to a more suitable wavelength at an intended biological site, thus …

Bioluminescence tomography is a preclinical imaging modality to locate and quantify
internal bioluminescent sources from surface measurements, which experienced rapid …

Abstract Background The development of Cone-beam X-ray luminescence computed
tomography (CB-XLCT) has allowed the quantitative in-depth biological imaging, but with a …

Significance Rapid estimation of the depth and margins of fluorescence targets buried below
the tissue surface could improve upon current image-guided surgery techniques for tumor …

Optical molecular imaging is an important technique of studies at molecular level and
provides promising tools to non-invasively delineate in vivo physiological and pathological …

Abstract Yb 3+ and Er 3+ doped LiYF 4: RE 3+(RE= Yb, Er) phosphors have been
synthesized using solid state reaction of pre-converted rare earth fluorides and lithium …

In vivo wide-field brain microscopy has remained a non-trivial challenge in life science
research, which would provide indispensable preclinical insight into the whole-brain …

Molecular imaging is very promising technique used for surgical guidance, which requires
advancements related to properties of imaging agents and subsequent data retrieval …

Cone-beam X-ray luminescence computed tomography (CB-XLCT) emerged as a novel
hybrid technique for early detection of small tumors in vivo. However, severe ill-posedness is …

This thesis describes experiments and analyses which push the frontier per what one can
learn from optically emitting exogenous contrast agents in living tissue. The first set of …