The classical role of AMP-activated protein kinase (AMPK) is as a cellular energy sensor
activated by falling energy status, signalled by increases in AMP to ATP and ADP to ATP …

Cancer is characterized as a complex disease caused by coordinated alterations of multiple
signaling pathways. The Ras/RAF/MEK/ERK (MAPK) signaling is one of the best-defined …

The AMPK (AMP-activated protein kinase) and TOR (target-of-rapamycin) pathways are
interlinked, opposing signaling pathways involved in sensing availability of nutrients and …

Lipid metabolism disorders are the primary causes for the occurrence and progression of
various liver diseases, including non-alcoholic fatty liver disease (NAFLD) and alcoholic fatty …

Non-alcoholic fatty liver disease (NAFLD) is a quickly emerging global health problem
representing the most common chronic liver disease in the world. Atherosclerotic …

The ever-increasing prevalence of noncommunicable diseases (NCDs) represents a major
public health burden worldwide. The most common form of NCD is metabolic diseases …

Andrographolide is a labdane diterpene and the main active ingredient isolated from the
herb Andrographis paniculata. Andrographolide possesses diverse biological effects …

Cholesterol is a lipid molecule that plays an essential role in a number of biological
processes, both physiological and pathological. It is an essential structural constituent of cell …

NEUROD1 is a transcription factor that helps maintain a mature phenotype of pancreatic β
cells. Disruption of Neurod1 during pancreatic development causes severe neonatal …

Objective Obesity-related chronic inflammation plays an important role in the development of
Metabolic Associated Fatty Liver Disease (MAFLD). Although the contribution of the pro …