The pathology of Alzheimer disease (AD) damages structural and functional brain networks,
resulting in cognitive impairment. The results of recent connectomics studies have now …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the most
common cause of dementia. Beta-amyloid (Aβ) deposition and neurofibrillary tangles (NFTs) …

Previous MRI studies reported cortical iron accumulation in early-onset (EOAD) compared to
late-onset (LOAD) Alzheimer disease patients. However, the pattern and origin of iron …

Early-onset Alzheimer disease (EOAD), which presents in patients younger than 65 years,
has frequently been described as having different features from those of late-onset …

Alzheimer's disease (AD) is the most common neurodegenerative disease in elderly
individuals. We conducted this study to examine whether alterations in the fractional …

Introduction Recent studies have shown that pathologically defined subtypes of Alzheimer's
disease (AD) represent distinctive atrophy patterns and clinical characteristics. We …

Abstract Early-onset (age< 65) Alzheimer's disease is associated with greater non-amnestic
cognitive symptoms and neuropathological burden than late-onset disease. It is not fully …

Late-onset and early-onset Alzheimer's disease (LOAD, EOAD) affect different neural
systems and may be separate nosographic entities. The most striking differences are in the …

Objectives We aimed to define brain iron distribution patterns in subtypes of early-onset
Alzheimer's disease (EOAD) by the use of quantitative susceptibility mapping (QSM) …

Early-onset Alzheimer's disease (EOAD) is characterized by greater nonmemory
dysfunctions, more rapid progression, and greater hypometabolism and atrophy than late …