Abstract Type 2 diabetes (T2D) is caused by insulin resistance and insufficient insulin
secretion. Evidence has increasingly indicated that pancreatic β-cell dysfunction is the …

Type 1 diabetes (T1D) results from autoimmune destruction of β-cells in the pancreas.
Protein tyrosine phosphatases (PTPs) are candidate genes for T1D and play a key role in …

Lipotoxicity can lead to beta‐cell dysfunction and apoptosis because it induces oxidative
stress. Recent studies have found that Irisin prevents pancreatic beta‐cell dysfunction …

Uncovering the pathogenesis of obesity complicated with papillary thyroid carcinoma via
bioinformatics and experimental validation - PMC Back to Top Skip to main content NIH NLM …

Abstract Ubiquitin-Specific Peptidases (USPs) are the main members of deubiquitinases
(DUBs) that catalyze removing ubiquitin chains from target proteins, thereby modulating their …

Aims/hypothesis Several studies have reported associations between specific proteins and
type 2 diabetes risk in European populations. To better understand the role played by …

The loss of functional pancreatic β-cell mass is an important hallmark of both type 1 and type
2 diabetes. The RNA-binding protein NOVA1 is expressed in human and rodent pancreatic …

An altered gut microbiota is associated with type 1 diabetes (T1D), affecting the production
of short-chain fatty acids (SCFA) and glucose homeostasis. We previously demonstrated that …

Purpose Prolonged exposure to plasma free fatty acids (FFAs) leads to impaired glucose
tolerance (IGT) which can progress to type 2 diabetes (T2D) in the absence of timely and …

Background Diabetes is a spectrum of metabolic diseases affecting millions of people
worldwide. The loss of pancreatic β-cell mass by either autoimmune destruction or …