Intermittent hypoxia (IH) is a hallmark manifestation of obstructive sleep apnea (OSA), a
widespread disorder of breathing. This Review focuses on the role of hypoxia-inducible …

Obstructive sleep apnea (OSA) is a respiratory condition during sleep caused by repeated
pauses in breathing due to upper airway obstruction. It is estimated that OSA affects 30% of …

For the development of new treatment strategies against cancer, understanding signaling
networks and their changes upon drug response is a promising approach to identify new …

Chronic intermittent hypoxia (CIH) is the dominant pathological feature of human obstructive
sleep apnoea (OSA), which is highly prevalent and associated with cardiovascular and renal …

Non‐technical summary Exposure to chronic intermittent hypoxia (CIH) leads to chronically
elevated sympathetic nerve activity (SNA) and mean arterial pressure (MAP) with …

Rationale: Obstructive sleep apnea, which is characterized by intermittent hypoxia (IH)
during sleep, has emerged as an independent risk factor for cardiovascular disease …

The mechanism of vascular endothelial dysfunction (VED) and cardiovascular disease in
obstructive sleep apnea (OSA) is unknown. We performed a comprehensive evaluation of …

Like humans with sleep apnea, rats exposed to chronic intermittent hypoxia (CIH)
experience arterial hypoxemias and develop hypertension characterized by exaggerated …

The carotid body (CB) plays a main role in the maintenance of the oxygen homeostasis. The
hypoxic stimulation of the CB increases the chemosensory discharge, which in turn elicits …

Introduction: Sleep apnea (SA) is highly prevalent in patients with chronic kidney disease
and may contribute to the development and/or progression of this condition. Previous …