Models and mechanisms of vascular dementia
Vascular dementia (VaD) is the second leading form of dementia after Alzheimer's disease
(AD) plaguing the elderly population. VaD is a progressive disease caused by reduced …
(AD) plaguing the elderly population. VaD is a progressive disease caused by reduced …
[HTML][HTML] Importance of the brain corticosteroid receptor balance in metaplasticity, cognitive performance and neuro-inflammation
ER De Kloet, OC Meijer, AF de Nicola… - Frontiers in …, 2018 - Elsevier
Bruce McEwen's discovery of receptors for corticosterone in the rat hippocampus introduced
higher brain circuits in the neuroendocrinology of stress. Subsequently, these receptors …
higher brain circuits in the neuroendocrinology of stress. Subsequently, these receptors …
Impaired glymphatic transport in spontaneously hypertensive rats
The glymphatic system is a brainwide CSF transport system that uses the perivascular space
for fast inflow of CSF. Arterial pulsations are a major driver of glymphatic CSF inflow, and …
for fast inflow of CSF. Arterial pulsations are a major driver of glymphatic CSF inflow, and …
Current and emerging avenues for Alzheimer's disease drug targets
R Loera‐Valencia, A Cedazo‐Minguez… - Journal of internal …, 2019 - Wiley Online Library
Abstract Alzheimer's disease (AD), the most frequent cause of dementia, is escalating as a
global epidemic, and so far, there is neither cure nor treatment to alter its progression. The …
global epidemic, and so far, there is neither cure nor treatment to alter its progression. The …
Spontaneous white matter damage, cognitive decline and neuroinflammation in middle-aged hypertensive rats: an animal model of early-stage cerebral small vessel …
D Kaiser, G Weise, K Möller, J Scheibe, C Pösel… - Acta neuropathologica …, 2014 - Springer
Introduction Cerebral small vessel disease (cSVD) is one of the most prevalent neurological
disorders. The progressive remodeling of brain microvessels due to arterial hypertension or …
disorders. The progressive remodeling of brain microvessels due to arterial hypertension or …
Açai berry mitigates vascular dementia-induced neuropathological alterations modulating Nrf-2/Beclin1 pathways
The second-most common cause of dementia is vascular dementia (VaD). The majority of
VaD patients experience cognitive impairment, which is brought on by oxidative stress and …
VaD patients experience cognitive impairment, which is brought on by oxidative stress and …
The pathology of “vascular dementia”: a critical update
KA Jellinger - Journal of Alzheimer's Disease, 2008 - content.iospress.com
The prevalence, morphology and pathogenesis of vascular dementia (VaD), recently termed
vascular cognitive disorder (VCD), are a matter of discussion. VaD is suggested in 8–15% of …
vascular cognitive disorder (VCD), are a matter of discussion. VaD is suggested in 8–15% of …
Hypoxia promotes tau hyperphosphorylation with associated neuropathology in vascular dysfunction
Background Hypertension-induced microvascular brain injury is a major vascular contributor
to cognitive impairment and dementia. We hypothesized that chronic hypoxia promotes the …
to cognitive impairment and dementia. We hypothesized that chronic hypoxia promotes the …
Biological correlates of adult cognition: Midlife in the United States (MIDUS)
AS Karlamangla, D Miller-Martinez, ME Lachman… - Neurobiology of …, 2014 - Elsevier
Multiple biological processes are related to cognitive impairment in older adults, but their
combined impact on cognition in midlife is not known. Using an array of measurements …
combined impact on cognition in midlife is not known. Using an array of measurements …
Blood‐brain barrier damage in vascular dementia
M Ueno, Y Chiba, K Matsumoto, R Murakami… - …, 2016 - Wiley Online Library
New findings on flow or drainage pathways of brain interstitial fluid and cerebrospinal fluid
have been made. The interstitial fluid flow has an effect on the passage of blood‐borne …
have been made. The interstitial fluid flow has an effect on the passage of blood‐borne …