Overcoming barriers in photodynamic therapy harnessing nano-formulation strategies
Photodynamic therapy (PDT) has been extensively investigated for decades for tumor
treatment because of its non-invasiveness, spatiotemporal selectivity, lower side-effects, and …
treatment because of its non-invasiveness, spatiotemporal selectivity, lower side-effects, and …
Autophagy and autophagy-related proteins in cancer
X Li, S He, B Ma - Molecular cancer, 2020 - Springer
Autophagy, as a type II programmed cell death, plays crucial roles with autophagy-related
(ATG) proteins in cancer. Up to now, the dual role of autophagy both in cancer progression …
(ATG) proteins in cancer. Up to now, the dual role of autophagy both in cancer progression …
The mechanisms of sorafenib resistance in hepatocellular carcinoma: theoretical basis and therapeutic aspects
W Tang, Z Chen, W Zhang, Y Cheng, B Zhang… - Signal transduction and …, 2020 - nature.com
Sorafenib is a multikinase inhibitor capable of facilitating apoptosis, mitigating angiogenesis
and suppressing tumor cell proliferation. In late-stage hepatocellular carcinoma (HCC) …
and suppressing tumor cell proliferation. In late-stage hepatocellular carcinoma (HCC) …
PI3K/AKT/mTOR signaling in gastric cancer: Epigenetics and beyond
S Fattahi, F Amjadi-Moheb, R Tabaripour, GH Ashrafi… - Life Sciences, 2020 - Elsevier
Abstract PI3K/AKT/mTOR pathway is one of the most important signaling pathways involved
in normal cellular processes. Its aberrant activation modulates autophagy, epithelial …
in normal cellular processes. Its aberrant activation modulates autophagy, epithelial …
The roles of autophagy in cancer
CW Yun, SH Lee - International journal of molecular sciences, 2018 - mdpi.com
Autophagy is an intracellular degradative process that occurs under several stressful
conditions, including organelle damage, the presence of abnormal proteins, and nutrient …
conditions, including organelle damage, the presence of abnormal proteins, and nutrient …
mTOR signaling in cancer and mTOR inhibitors in solid tumor targeting therapy
T Tian, X Li, J Zhang - International journal of molecular sciences, 2019 - mdpi.com
The mammalian or mechanistic target of rapamycin (mTOR) pathway plays a crucial role in
regulation of cell survival, metabolism, growth and protein synthesis in response to upstream …
regulation of cell survival, metabolism, growth and protein synthesis in response to upstream …
Autophagy and disease: unanswered questions
Y Yang, DJ Klionsky - Cell Death & Differentiation, 2020 - nature.com
Autophagy is a process in which intracellular components and dysfunctional organelles are
delivered to the lysosome for degradation and recycling. Autophagy has various …
delivered to the lysosome for degradation and recycling. Autophagy has various …
[HTML][HTML] Role and regulation of autophagy in cancer
R Rakesh, LC PriyaDharshini, KM Sakthivel… - … et Biophysica Acta (BBA …, 2022 - Elsevier
Autophagy is an intracellular self-degradative mechanism which responds to cellular
conditions like stress or starvation and plays a key role in regulating cell metabolism, energy …
conditions like stress or starvation and plays a key role in regulating cell metabolism, energy …
Nanomaterials: A comprehensive review of applications, toxicity, impact, and fate to environment
The present era is considered the nanotech age. Nanomaterials have gained a great deal of
importance in the field of technology, engineering, and medicine progression because of …
importance in the field of technology, engineering, and medicine progression because of …
Elucidating the mechanisms of Temozolomide resistance in gliomas and the strategies to overcome the resistance.
Temozolomide (TMZ) is a first-choice alkylating agent inducted as a gold standard therapy
for glioblastoma multiforme (GBM) and astrocytoma. A majority of patients do not respond to …
for glioblastoma multiforme (GBM) and astrocytoma. A majority of patients do not respond to …