Our incomplete understanding of the link between Alzheimer's Disease pathology and
symptomatology is a crucial obstacle for therapeutic success. Recently, translational studies …

Fast-spiking parvalbumin (PV) interneurons are inhibitory interneurons with unique
morphological and functional properties that allow them to precisely control local circuitry …

Background: Neuronal-and circuit-level abnormalities of excitation and inhibition are shown
to be associated with tau and amyloid-beta (Aβ) in preclinical models of Alzheimer's disease …

An early disruption of neuronal excitation–inhibition (E–I) balance in preclinical animal
models of Alzheimer's disease (AD) has been frequently reported, but is difficult to measure …

Background Neuronal hyperexcitability and inhibitory interneuron dysfunction are frequently
observed in preclinical animal models of Alzheimer's disease (AD). This study investigates …

Background Graph theory and machine learning have been shown to be effective ways of
classifying different stages of Alzheimer's disease (AD). Most previous studies have only …

An extensive electrophysiological literature has proposed a pathological 'slowing'of
neuronal activity in patients on the Alzheimer's disease spectrum. Supported by numerous …

Alzheimer's disease (AD) and other tauopathies are characterized by the aggregation of tau
into soluble and insoluble forms (including tangles and neuropil threads). In humans, a …

Abstract Vascular Cognitive Impairment (VCI) is the second most prevalent dementia after
Alzheimer's Disease (AD), and cerebrovascular disease (CBVD) is a major comorbid …

Alzheimer's disease (AD) studies on animal models, and humans showed a tendency of the
brain tissue to become hyperexcitable and hypersynchronized, causing neurodegeneration …