During the past 30 yr, investigating the physiology of eating behaviors has generated a truly
vast literature. This is fueled in part by a dramatic increase in obesity and its comorbidities …

The pathophysiology of anorexia nervosa (AN) and bulimia nervosa (BN) are still poorly
understood, but psychobiological models have proposed a key role for disturbances in the …

Stress can cause overconsumption of palatable high caloric food. Despite the important role
of stress eating in obesity and (binge) eating disorders, its underlying neural mechanisms …

It has been proposed that binge eating reflects a pathological compulsion driven by the
“addictive” properties of foods. Proponents of this argument highlight the large degree of …

Orexin peptides comprise two neuropeptides, orexin A and orexin B, that bind two G-protein
coupled receptors (GPCRs), orexin receptor 1 (OXR1) and orexin receptor 2 (OXR2) …

Compulsive alcohol drinking, where intake persists regardless of adverse consequences,
plays a major role in the substantial costs of alcohol use disorder. However, the processes …

In this review study, we aimed to introduce the orexinergic system as an important signaling
pathway involved in a variety of cognitive functions such as memory, motivation, and reward …

Chronic stress fuels the consumption of palatable food and can enhance obesity
development. While stress-and feeding-controlling pathways have been identified, how …

Ingestive behavior is controlled by multiple distinct peripheral and central physiological
mechanisms that ultimately determine whether a particular food should be accepted or …

Drug-associated sensory cues increase motivation for drug and the orexin system is
importantly involved in this stimulus-enhanced motivation. Ventral tegmental area (VTA) is a …