Protein–excipient interactions: Mechanisms and biophysical characterization applied to protein formulation development

TJ Kamerzell, R Esfandiary, SB Joshi… - Advanced drug delivery …, 2011 - Elsevier
The purpose of this review is to demonstrate the critical importance of understanding protein–
excipient interactions as a key step in the rational design of formulations to stabilize and …

On the adsorption of proteins on solid surfaces, a common but very complicated phenomenon

K Nakanishi, T Sakiyama, K Imamura - Journal of bioscience and …, 2001 - Elsevier
Adsorption of proteins on solid surfaces and their interaction are major concerns in a
number of fields such as biology, medicine, biotechnology and food processing, and play an …

Bioceramics for drug delivery

D Arcos, M Vallet-Regi - Acta Materialia, 2013 - Elsevier
Bioceramics, such as calcium phosphate ceramics and cements and silica-based glasses,
are widely used as components of implants for bone and teeth restoration. Nowadays, the …

Progress on the preparation of nanocrystalline apatites and surface characterization: Overview of fundamental and applied aspects

J Gómez-Morales, M Iafisco, JM Delgado-López… - Progress in Crystal …, 2013 - Elsevier
Nanocrystalline calcium phosphate apatites constitute the main inorganic part of hard
tissues, and a growing focus is devoted to prepare synthetic analogs, so-called “biomimetic” …

Biomimetic hydroxyapatite–drug nanocrystals as potential bone substitutes with antitumor drug delivery properties

B Palazzo, M Iafisco, M Laforgia… - Advanced Functional …, 2007 - Wiley Online Library
Abstract This Full Paper investigates the adsorption and desorption of the anticancer drugs
cis‐diamminedichloroplatinum (II)(CDDP, cisplatin) and the new platinum (II) complex di …

Impacts of the surface charge property on protein adsorption on hydroxyapatite

G Yin, Z Liu, J Zhan, F Ding, N Yuan - Chemical Engineering Journal, 2002 - Elsevier
Knowledge of the adsorption mechanism of biological molecules on hydroxyapatite (HAP) is
essential to the application of HAP chromatography and to the development of HAP-based …

Pharmaceutical protein solids: Drying technology, solid-state characterization and stability

Y Chen, TT Mutukuri, NE Wilson, QT Zhou - Advanced drug delivery …, 2021 - Elsevier
Despite the boom in biologics over the past decade, the intrinsic instability of these large
molecules poses significant challenges to formulation development. Almost half of all …

[图书][B] Biomimetic nanoceramics in clinical use: from materials to applications

M Vallet-Regí, DA Navarrete, D Arcos - 2008 - books.google.com
Recent developments in nanostructured materials have led to a shift in focus away from the
replacement of tissues and towards regeneration. Nanoceramics with biomimetic properties …

Adsorption and release of BMP‐2 on nanocrystalline apatite‐coated and uncoated hydroxyapatite/β‐tricalcium phosphate porous ceramics

H Autefage, F Briand‐Mésange… - … Research Part B …, 2009 - Wiley Online Library
The association of bone morphogenetic proteins (BMPs) with calcium phosphate
bioceramics is known to confer them osteoinductive properties. The aim of this study was to …

Interactions of cisplatin with calcium phosphate nanoparticles: in vitro controlled adsorption and release

A Barroug, LT Kuhn, LC Gerstenfeld… - Journal of …, 2004 - Wiley Online Library
A new system for the local delivery of chemotherapy to malignant solid tumors has been
developed based on calcium phosphate (CaP) nanoparticles. The adsorption of the anti …