Parkinson's Disease (PD) is a neurodegenerative disorder characterized, in part, by the loss
of dopaminergic neurons within the nigral-striatal pathway. Multiple lines of evidence …

Nitric oxide (NO) is a multifunctional signalling molecule and a neurotransmitter that plays
an important role in physiological and pathophysiological processes. In physiological …

Inflammation in Parkinson's disease (PD) is a new concept that has gained ground due to
the potential of mitigating dopaminergic neuron death by decreasing inflammation. The …

Background: The pathogenesis of Parkinson's disease (PD) is not fully understood. Together
with some important physiological functions in the Central Nervous System (CNS), nitric …

Inflammatory mechanisms are proposed to play a role in l-DOPA-induced dyskinesia.
Cyclooxygenase-2 (COX2) contributes to inflammation pathways in the periphery and is …

In the Central Nervous System (CNS), Nitric Oxide (NO) is mainly biosynthesized by
neuronal Nitric Oxide Synthase (nNOS). The dysregulated activation of nNOS in neurons is …

It is well known that nitric oxide (NO) interacts with dopamine (DA) within the striatal circuitry.
The anti-dyskinetic properties of NO synthase (NOS) inhibitors demonstrate the importance …

Extrapyramidal side effects (EPS) can be induced by neuroleptics that regulate the
expression of transcription factor FosB and dopaminergic mediator DARPP-32 in the …

Nitric oxide (NO) plays a pivotal role in integrating dopamine transmission in the basal
ganglia and has been implicated in the pathogenesis of Parkinson disease (PD). The …

A growing bulk of evidence suggests that cannabinoid system plays a pivotal role in the
control of hyperexcitability phenomena. Notwithstanding, the anticonvulsant action of …