Involvement of neural transient receptor potential channels in peripheral inflammation

HA Silverman, A Chen, NL Kravatz… - Frontiers in …, 2020 - frontiersin.org
Transient receptor potential (TRP) channels are a superfamily of non-selective cation
channels that act as polymodal sensors in many tissues throughout mammalian organisms …

TRPV4—a missing link between mechanosensation and immunity

L Michalick, WM Kuebler - Frontiers in immunology, 2020 - frontiersin.org
Transient receptor potential vanilloid-type 4 (TRPV4) cation channel is widely expressed in
all tissues as well as in immune cells and its function as mechanosensitive Ca2+ channel …

The ion channel TRPV1 regulates the activation and proinflammatory properties of CD4+ T cells

S Bertin, Y Aoki-Nonaka, PR De Jong, LL Nohara… - Nature …, 2014 - nature.com
Abstract TRPV1 is a Ca2+-permeable channel studied mostly as a pain receptor in sensory
neurons. However, its role in other cell types is poorly understood. Here we found that …

[HTML][HTML] Distribution and expression of non-neuronal transient receptor potential (TRPV) ion channels in rosacea

M Sulk, S Seeliger, J Aubert, VD Schwab… - Journal of investigative …, 2012 - Elsevier
Rosacea is a frequent chronic inflammatory skin disease of unknown etiology. Because
early rosacea reveals all characteristics of neurogenic inflammation, a central role of …

New insights on the role of TRP channels in calcium signalling and immunomodulation: review of pathways and implications for clinical practice

S Froghi, CR Grant, R Tandon, A Quaglia… - Clinical reviews in …, 2021 - Springer
Calcium is the most abundant mineral in the human body and is central to many
physiological processes, including immune system activation and maintenance. Studies …

Role of transient receptor potential vanilloid 4 in neutrophil activation and acute lung injury

J Yin, L Michalick, C Tang, A Tabuchi… - American journal of …, 2016 - atsjournals.org
The cation channel transient receptor potential vanilloid (TRPV) 4 is expressed in
endothelial and immune cells; however, its role in acute lung injury (ALI) is unclear. The …

Cannabidiol causes endothelium-dependent vasorelaxation of human mesenteric arteries via CB1 activation

CP Stanley, WH Hind, C Tufarelli… - Cardiovascular …, 2015 - academic.oup.com
Aims The protective effects of cannabidiol (CBD) have been widely shown in preclinical
models and have translated into medicines for the treatment of multiple sclerosis and …

Endocannabinoids modulate human blood–brain barrier permeability in vitro

WH Hind, C Tufarelli, M Neophytou… - British journal of …, 2015 - Wiley Online Library
Background and Purpose Endocannabinoids alter permeability at various epithelial barriers,
and cannabinoid receptors and endocannabinoid levels are elevated by stroke, with …

A molecular signature in blood identifies early Parkinson's disease

L Molochnikov, JM Rabey, E Dobronevsky… - Molecular …, 2012 - Springer
Background The search for biomarkers in Parkinson's disease (PD) is crucial to identify the
disease early and monitor the effectiveness of neuroprotective therapies. We aim to assess …

Oxidative stress mediates thalidomide-induced pain by targeting peripheral TRPA1 and central TRPV4

F De Logu, G Trevisan, IM Marone, E Coppi… - BMC biology, 2020 - Springer
Background The mechanism underlying the pain symptoms associated with
chemotherapeutic-induced peripheral neuropathy (CIPN) is poorly understood. Transient …